Role of Metabolomics in Pathogenesis and Prompt Diagnosis of Gastric Cancer Metastasis-A Systematic Review.
Role of Metabolomics in Pathogenesis and Prompt Diagnosis of Gastric Cancer Metastasis-A Systematic Review.
复制标题
代谢组学在发病机理和及时诊断胃癌转移的作用。
DOI：
10.3390/diagnostics13223401
复制
发表时间：
2023-11-08
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
简介：胃癌是第四大最常诊断的癌症形式，也是全球癌症相关死亡的第三大原因。本综述的目的是确定个体代谢生物标志物及其与准确诊断值的关联，从而可以预测胃癌转移。材料与方法：通过关键词搜索，发现 13 年期间的 83 篇文章。一篇因为不是英文写的而被淘汰，另外两篇是在选定时期之外出版的。在消除重复、不相关的文章、系统评价和限制访问研究后，七篇科学论文符合本次调查的资格。结果：发现了对胃癌转移和阐明转移过程的代谢途径具有预测价值的新代谢生物标志物。致病过程可概述如下：促氧化能力、T细胞失活、细胞周期停滞、能量产生和线粒体酶损伤、细胞活力和促凋亡作用、胶原细胞外基质降解增强、迁移、侵袭、结构蛋白合成和肿瘤血管生成。结论：代谢生物标志物已被公认为胃癌转移分子过程中的独立危险因素，具有良好的诊断和预后价值。
Introduction: Gastric cancer is the fourth most frequently diagnosed form of cancer and the third leading cause of cancer-related mortality worldwide. The aim of this review is to identify individual metabolic biomarkers and their association with accurate diagnostic values, which can predict gastric cancer metastasis. Materials and Methods: After searching the keywords, 83 articles were found over a period of 13 years. One was eliminated because it was not written in English, and two were published outside the selected period. Seven scientific papers were qualified for this investigation after eliminating duplicates, non-related articles, systematic reviews, and restricted access studies. Results: New metabolic biomarkers with predictive value for gastric cancer metastasis and for elucidating metabolic pathways of the metastatic process have been found. The pathogenic processes can be outlined as follows: pro-oxidant capacity, T-cell inactivation, cell cycle arrest, energy production and mitochondrial enzyme impairment, cell viability and pro-apoptotic effect, enhanced degradation of collagen extracellular matrix, migration, invasion, structural protein synthesis, and tumoral angiogenesis. Conclusion: Metabolic biomarkers have been recognized as independent risk factors in the molecular process of gastric cancer metastasis, with good diagnostic and prognostic value.
登录
查看更多内容
无细胞循环甲基化 SEPT9 用于结直肠癌的无创诊断和监测
影响因子：
--
作者：
Fu B;Yan P;Zhang S;Lu Y;Pan L;Tang W;Chen S;Chen S;Zhang A;Liu W
通讯作者：
Liu W
影响因子：
--
作者：
Kim J;Yum S;Kang C;Kang SJ
通讯作者：
Kang SJ
影响因子：
6.4
作者：
Langbein, Sigrun;Frederiks, Wilma M.;Coy, Johannes F.
通讯作者：
Coy, Johannes F.
影响因子：
8.4
作者：
Ferro, Ana;Peleteiro, Barbara;Lunet, Nuno
通讯作者：
Lunet, Nuno
影响因子：
1.6
作者：
Hou, Lin;Zhang, Xueying;Liu, Ziling
通讯作者：
Liu, Ziling