Associations of PM₂.₅ constituents and sources with hospital admissions: analysis of four counties in Connecticut and Massachusetts (USA) for persons ≥ 65 years of age.
Associations of PM₂.₅ constituents and sources with hospital admissions: analysis of four counties in Connecticut and Massachusetts (USA) for persons ≥ 65 years of age.
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DOI：
10.1289/ehp.1306656
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发表时间：
2014-02
影响因子：
10.4
通讯作者：
Peng RD
中科院分区：
文献类型：
--
作者：
Bell ML;Ebisu K;Leaderer BP;Gent JF;Lee HJ;Koutrakis P;Wang Y;Dominici F;Peng RD
背景：流行病学研究表明，短期暴露于PM2.5和住院之间存在关联。粒子的化学成分因地点和时间而异。确定最有害的成分和来源是一个重要的健康和监管问题。目的：我们研究了污染源与心血管和呼吸系统疾病住院风险的关系。方法：我们获得了康涅狄格州和马萨诸塞州四个县的PM2.5过滤器样品，并分析了它们的PM2.5元素。源解析用于估计来自源（交通、道路灰尘、石油燃烧和海盐以及代表燃煤和其他源的区域源）的每日PM2.5贡献。通过时间序列分析（2000年8月至2004年2月）估计了医疗保险人群（> 333，000人≥ 65岁）每日PM2.5成分和来源与心血管和呼吸系统住院风险之间的关系。结果如下：PM2.5总质量和PM2.5道路灰尘贡献与心血管住院相关，PM2.5成分钙，炭黑，钒和锌也是如此。对于呼吸道住院治疗，观察到与PM2.5道路灰尘、海盐以及铝、钙、氯、黑碳、镍、硅、钛和钒有关。影响估计一般是强大的其他成分的共污染物的调整。同一天PM2.5道路灰尘（1.71 μg/m3）的四分位数范围增加分别与心血管和呼吸道入院增加2.11%（95% CI：1.09，3.15%）和3.47%（95% CI：2.03，4.94%）相关。结论：我们的研究结果表明，一些颗粒源和成分比其他颗粒更有害，在康涅狄格州/马萨诸塞州地区，最有害的颗粒包括黑碳，钙和道路灰尘PM2.5。引文：Bell ML，Ebisu K，Leaderer BP，Gent JF，Lee HJ，Koutrakis P，Wang Y，Dominici F，Peng RD. 2014. PM2.5成分和来源与住院率的关系：对康涅狄格州和马萨诸塞州（美国）四个县≥ 65岁人群的分析。环境健康展望122：138-144; http：dx.doi.org/10.1289/ehp.1306656
Background: Epidemiological studies have demonstrated associations between short-term exposure to PM2.5 and hospital admissions. The chemical composition of particles varies across locations and time periods. Identifying the most harmful constituents and sources is an important health and regulatory concern. Objectives: We examined pollutant sources for associations with risk of hospital admissions for cardiovascular and respiratory causes. Methods: We obtained PM2.5 filter samples for four counties in Connecticut and Massachusetts and analyzed them for PM2.5 elements. Source apportionment was used to estimate daily PM2.5 contributions from sources (traffic, road dust, oil combustion, and sea salt as well as a regional source representing coal combustion and other sources). Associations between daily PM2.5 constituents and sources and risk of cardiovascular and respiratory hospitalizations for the Medicare population (> 333,000 persons ≥ 65 years of age) were estimated with time-series analyses (August 2000–February 2004). Results: PM2.5 total mass and PM2.5 road dust contribution were associated with cardiovascular hospitalizations, as were the PM2.5 constituents calcium, black carbon, vanadium, and zinc. For respiratory hospitalizations, associations were observed with PM2.5 road dust, and sea salt as well as aluminum, calcium, chlorine, black carbon, nickel, silicon, titanium, and vanadium. Effect estimates were generally robust to adjustment by co-pollutants of other constituents. An interquartile range increase in same-day PM2.5 road dust (1.71 μg/m3) was associated with a 2.11% (95% CI: 1.09, 3.15%) and 3.47% (95% CI: 2.03, 4.94%) increase in cardiovascular and respiratory admissions, respectively. Conclusions: Our results suggest some particle sources and constituents are more harmful than others and that in this Connecticut/Massachusetts region the most harmful particles include black carbon, calcium, and road dust PM2.5. Citation: Bell ML, Ebisu K, Leaderer BP, Gent JF, Lee HJ, Koutrakis P, Wang Y, Dominici F, Peng RD. 2014. Associations of PM2.5 constituents and sources with hospital admissions: analysis of four counties in Connecticut and Massachusetts (USA) for persons ≥ 65 years of age. Environ Health Perspect 122:138–144; http://dx.doi.org/10.1289/ehp.1306656
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影响因子：
10.4
作者：
Ebisu K;Bell ML
通讯作者：
Bell ML
DOI：
10.1038/sj.jea.7500262
发表时间：
2003-03-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Cyrys, J;Heinrich, J;Brunekreef, B
通讯作者：
Brunekreef, B
DOI：
10.1097/ede.0b013e3181812bb7
发表时间：
2008-09
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Franklin M;Koutrakis P;Schwartz P
通讯作者：
Schwartz P
影响因子：
11.4
作者：
Kim, E;Hopke, PK;Wilson, WE
通讯作者：
Wilson, WE
影响因子：
120.7
作者：
Dominici, F;Peng, RD;Samet, JM
通讯作者：
Samet, JM