Airborne PM2.5 chemical components and low birth weight in the northeastern and mid-Atlantic regions of the United States.
Airborne PM2.5 chemical components and low birth weight in the northeastern and mid-Atlantic regions of the United States.
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DOI：
10.1289/ehp.1104763
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发表时间：
2012-12
影响因子：
10.4
通讯作者：
Bell ML
中科院分区：
文献类型：
--
作者：
Ebisu K;Bell ML
背景：先前关于空气污染物和出生结果的研究报告的结果不一致。≤2.5µm （PM2.5）组成的颗粒物化学成分具有空间异质性，这可能导致PM2.5研究之间的差异。目的：我们探讨了足月出生体重是否受到PM2.5、PM10 （PM≤10µm）和气态污染物的影响。方法：我们计算了2000-2007年美国东北部和大西洋中部各州新生儿在怀孕期间和每个孕期暴露PM2.5化学成分、PM10、PM2.5、一氧化碳、二氧化氮、臭氧和二氧化硫的暴露。暴露与低出生体重（LBW）风险之间的关系根据家庭、个人特征和地区进行调整。相互作用术语用于调查风险是否因种族或性别而异。结果：PM2.5的几种化学成分与LBW有关。PM2.5每增加四分位数范围，铝、碳、镍和钛的风险分别增加4.9% （95% CI: 3.4, 6.5%）、4.7%（3.2,6.2%）、5.7%（2.7,8.8%）和5.0%（3.1,7.0%）。其他PM2.5化学成分与气态污染物存在相关性，但在多污染物模型中不具有统计学意义。与最高相对风险相关的妊娠期因污染物而异。对PM2.5元素碳和镍的影响估计，白人母亲的婴儿高于非裔美国母亲的婴儿，男性高于女性。结论：我们研究区域的大多数暴露水平符合美国环境保护局空气污染标准；然而，我们确定了PM2.5成分与LBW之间的关联。研究结果表明，一些PM2.5成分可能比其他成分更有害，一些人群可能特别容易受到影响。
Background: Previous studies on air pollutants and birth outcomes have reported inconsistent results. Chemical components of particulate matter ≤ 2.5 µm (PM2.5) composition are spatially -heterogeneous, which might contribute to discrepancies across PM2.5 studies. Objectives: We explored whether birth weight at term is affected by PM2.5, PM10 (PM ≤ 10 µm), and gaseous pollutants. Methods: We calculated exposures during gestation and each trimester for PM2.5 chemical components, PM10, PM2.5, carbon monoxide, nitrogen dioxide, ozone, and sulfur dioxide for births in 2000–2007 for states in the northeastern and mid-Atlantic United States. Associations between exposures and risk of low birth weight (LBW) were adjusted by family and individual characteristics and region. Interaction terms were used to investigate whether risk differs by race or sex. Results: Several PM2.5 chemical components were associated with LBW. Risk increased 4.9% (95% CI: 3.4, 6.5%), 4.7% (3.2, 6.2%), 5.7% (2.7, 8.8%), and 5.0% (3.1, 7.0%) per interquartile range increase of PM2.5 aluminum, elemental carbon, nickel, and titanium, respectively. Other PM2.5 chemical components and gaseous pollutants showed associations, but were not statistically significant in multipollutant models. The trimester associated with the highest relative risk differed among pollutants. Effect estimates for PM2.5 elemental carbon and nickel were higher for infants of white mothers than for those of African-American mothers, and for males than females. Conclusions: Most exposure levels in our study area were in compliance with U.S. Environmental Protection Agency air pollution standards; however, we identified associations between PM2.5 components and LBW. Findings suggest that some PM2.5 components may be more harmful than others, and that some groups may be particularly susceptible.
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DOI：
10.1097/ede.0b013e3181812bb7
发表时间：
2008-09
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Franklin M;Koutrakis P;Schwartz P
通讯作者：
Schwartz P
影响因子：
10.4
作者：
Ito K;Mathes R;Ross Z;Nádas A;Thurston G;Matte T
通讯作者：
Matte T
美国健康效应研究中PM（2.5）化学成分的空间和时间变化。
影响因子：
10.4
作者：
Bell ML;Dominici F;Ebisu K;Zeger SL;Samet JM
通讯作者：
Samet JM
影响因子：
10.4
作者：
Kannan S;Misra DP;Dvonch JT;Krishnakumar A
通讯作者：
Krishnakumar A
DOI：
10.1097/ede.0b013e3181f2f405
发表时间：
2010-11
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Bell ML;Belanger K;Ebisu K;Gent JF;Lee HJ;Koutrakis P;Leaderer BP
通讯作者：
Leaderer BP