Neuroinflammation in autism spectrum disorders.
Neuroinflammation in autism spectrum disorders.
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DOI：
10.1186/1742-2094-9-265
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发表时间：
2012-12-11
影响因子：
9.3
通讯作者：
Al-Ayadhi L
中科院分区：
文献类型：
--
作者：
El-Ansary A;Al-Ayadhi L
自闭症的神经生物学基础仍然知之甚少。然而，研究表明，环境因素、神经炎症以及遗传因素都是原因。本研究旨在探讨热休克蛋白（HSP）70、转化生长因子(TGF)-β2、Caspase 7、干扰素-γ (IFN-γ)在自闭症病理生理中的作用。测定20例沙特男性自闭症患者血浆中HSP70、TGF-β2、Caspase 7和INF-γ等与炎症相关的生化参数，并与19例年龄和性别匹配的对照样本进行比较。获得的数据记录了沙特自闭症患者的血浆HSP70、TGF-β2、Caspase 7和INF-γ明显高于年龄和性别匹配的对照组。TGF-β增加最少（49.04%），INF-γ增加最多（67.8%）。受试者工作特征（ROC）分析和预测图证明，测量参数记录了令人满意的特异性和敏感性水平，均可作为预测性生物标志物。所选参数的改变证实了神经炎症和细胞凋亡机制在自闭症病因学中的作用，以及使用HSP70、TGF-β2、Caspase 7和INF-γ作为预测性生物标志物的可能性，这些生物标志物可用于预测特定建议治疗或天然补充剂的安全性和有效性，从而为患者选择或调整剂量提供指导。
The neurobiological basis for autism remains poorly understood. However, research suggests that environmentalfactors and neuroinflammation, as well as genetic factors, are contributors. This study aims to test the role that might be played by heat shock protein (HSP)70, transforming growth factor (TGF)-β2, Caspase 7 and interferon-γ (IFN-γ)in the pathophysiology of autism. HSP70, TGF-β2, Caspase 7 and INF-γ as biochemical parameters related to inflammation were determined in plasma of 20 Saudi autistic male patients and compared to 19 age- and gender-matched control samples. The obtained data recorded that Saudi autistic patients have remarkably higher plasma HSP70, TGF-β2, Caspase 7 and INF-γ compared to age and gender-matched controls. INF-γ recorded the highest (67.8%) while TGF-β recorded the lowest increase (49.04%). Receiver Operating Characteristics (ROC) analysis together with predictiveness diagrams proved that the measured parameters recorded satisfactory levels of specificity and sensitivity and all could be used as predictive biomarkers. Alteration of the selected parameters confirm the role of neuroinflammation and apoptosis mechanisms in the etiology of autism together with the possibility of the use of HSP70, TGF-β2, Caspase 7 and INF-γ as predictive biomarkers that could be used to predict safety, efficacy of a specific suggested therapy or natural supplements, thereby providing guidance in selecting it for patients or tailoring its dose.
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来自沙特阿拉伯自闭症患者血浆中的单声道和肢体相关的促炎和促凋亡标记。
影响因子：
9.3
作者：
El-Ansary AK;Ben Bacha AG;Al-Ayadhi LY
通讯作者：
Al-Ayadhi LY
影响因子：
2.8
作者：
Al-Gadani, Y.;EI-Ansary, A.;Al-Ayadhi, L.
通讯作者：
Al-Ayadhi, L.
影响因子：
2.8
作者：
Al-Mosalem, O. A.;El-Ansary, A.;Al-Ayadhi, L.
通讯作者：
Al-Ayadhi, L.
影响因子：
3.9
作者：
Feinstein, DL;Galea, E;Reis, DJ
通讯作者：
Reis, DJ
影响因子：
16
作者：
Erener, Sueheda;Petrilli, Virginie;Hottigert, Michael O.
通讯作者：
Hottigert, Michael O.