Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia.
Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia.
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来自沙特阿拉伯自闭症患者血浆中的单声道和肢体相关的促炎和促凋亡标记。
DOI：
10.1186/1742-2094-8-142
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发表时间：
2011-10-15
影响因子：
9.3
通讯作者：
Al-Ayadhi LY
中科院分区：
文献类型：
--
作者：
El-Ansary AK;Ben Bacha AG;Al-Ayadhi LY
自闭症是一种发育障碍，其特征是社交和情感缺陷、语言障碍和刻板行为，在产后早期表现出来。本研究旨在阐明 K+、Na+、Ca2+、Mg2+ 和/或促炎和促凋亡生物标志物的绝对浓度和相对浓度之间的关系。在 25 名沙特自闭症男性患者的血浆中测定了 Na+、K+、Ca2+、Mg2+、Na+/K+、Ca2+/Mg2+ 以及作为促炎细胞因子的 IL6、TNFα 和作为促凋亡生物标志物的 caspase3，并与 16 个年龄和性别匹配的对照样本进行比较。获得的数据显示，与年龄和性别匹配的对照相比，沙特自闭症患者的血浆 caspase3、IL6、TNFα、Ca2+ 显着降低，K+ 显着升高。另一方面，自闭症患者的 Mg2+ 和 Na+ 没有显着改变。 Pearson 相关分析显示，测定的细胞因子和 caspase-3 的血浆浓度与 Ca2+ 和 Ca2+/K+ 比值呈正相关。接受者操作特征 (ROC) 分析证明，测量的参数记录了令人满意的特异性和敏感性水平。所选测量离子的改变证实氧化应激和线粒体能量产生缺陷可能导致自闭症的发病机制。此外，它还强调了测量的离子、IL6、TNFα 和 caspase3 之间的关系，作为一组信号传导途径，可能在产生这种日益普遍的疾病中发挥作用。假设并解释了离子在自闭症患者大脑可能的促炎症和促凋亡机制中的作用。
Autism is a developmental disorder characterized by social and emotional deficits, language impairments and stereotyped behaviors that manifest in early postnatal life. This study aims to clarify the relationship amongst absolute and relative concentrations of K+, Na+, Ca2+, Mg2+ and/or proinflammatory and proapoptotic biomarkers. Na+, K+, Ca2+, Mg2+, Na+/K+, Ca2+/Mg2+ together with IL6, TNFα as proinflammatory cytokines and caspase3 as proapoptotic biomarker were determined in plasma of 25 Saudi autistic male patients and compared to 16 age and gender matching control samples. The obtained data recorded that Saudi autistic patients have a remarkable lower plasma caspase3, IL6, TNFα, Ca2+ and a significantly higher K+ compared to age and gender matching controls. On the other hand both Mg2+ and Na+ were non-significantly altered in autistic patients. Pearson correlations revealed that plasma concentrations of the measured cytokines and caspase-3 were positively correlated with Ca2+ and Ca2+/K+ ratio. Reciever Operating Characteristics (ROC) analysis proved that the measured parameters recorded satisfactory levels of specificity and sensitivity. Alteration of the selected measured ions confirms that oxidative stress and defective mitochondrial energy production could be contributed in the pathogenesis of autism. Moreover, it highlights the relationship between the measured ions, IL6, TNFα and caspase3 as a set of signalling pathways that might have a role in generating this increasingly prevalent disorder. The role of ions in the possible proinflammation and proapoptic mechanisms of autistics' brains were hypothesized and explained.
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影响因子：
2.8
作者：
Al-Gadani, Y.;EI-Ansary, A.;Al-Ayadhi, L.
通讯作者：
Al-Ayadhi, L.
影响因子：
4.8
作者：
Cain, K;Langlais, C;Cohen, GM
通讯作者：
Cohen, GM
影响因子：
3.3
作者：
Ashwood, P;Wakefield, AJ
通讯作者：
Wakefield, AJ
影响因子：
3.3
作者：
Jyonouchi, H;Sun, SN;Le, H
通讯作者：
Le, H
影响因子：
3.3
作者：
Dimayuga, Filomena O.;Wang, Chunmei;Bruce-Keller, Amadora J.
通讯作者：
Bruce-Keller, Amadora J.