Multiple versus single virus respiratory infections: viral load and clinical disease severity in hospitalized children.
Multiple versus single virus respiratory infections: viral load and clinical disease severity in hospitalized children.
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多重与单个病毒呼吸道感染：住院儿童的病毒负荷和临床疾病严重程度。
DOI：
10.1111/j.1750-2659.2011.00265.x
复制
发表时间：
2012-01
影响因子：
4.4
通讯作者：
Englund JA
中科院分区：
文献类型：
--
作者：
Martin ET;Kuypers J;Wald A;Englund JA
请引用这篇论文：马丁等人。（2012）多重与单一病毒呼吸道感染：住院儿童的病毒载量和临床疾病严重程度。流感和其他呼吸道病毒6（1），71-77。 病毒病原体的分子检测已导致在患病儿童的呼吸道分泌物中检测到越来越多的多种病毒。多种病毒感染对临床表现和结局的临床影响尚不清楚。 目的比较儿童多种病毒感染与单一病毒感染的临床特征和病毒载量。 患者/方法2003年9月至2004年9月期间，通过定量PCR对西雅图儿童医院接受呼吸道疾病治疗的893例残留鼻洗液样本进行了呼吸道合胞病毒（RSV）、人偏肺病毒（hMPV）、流感病毒（Flu）、副流感病毒、腺病毒和冠状病毒（CoV）的评价。 从病历中提取疾病严重程度和患者特征。 结果在566份病毒阳性样本中发现103份（18%）合并感染。 在合并感染中最常检测到腺病毒（52%），其次是CoV（50%）。携带单一病毒的疾病增加了需氧量（P = 0.02）、住院时间延长（P = 0.002）、住院（P = 0.02）或重症监护室（P = 0.04）的风险。 对于Adv和PIV-1，多种病毒疾病的病毒载量（log 10拷贝/ml）显著低于单一病毒疾病（分别为4.2 vs. 5.6，P = 0.007和4.2 vs. 6.9，P <0.001）。 无论是否检测到其他病毒，RSV、Flu‐A、PIV‐3和hMPV病毒载量始终较高。 结论多种病毒检测的疾病与较轻的疾病相关。 病毒载量与多种病毒感染之间的关系是病毒特异性的，这可以作为区分多种病毒感染中的病毒的一种方法。
Please cite this paper as: Martin et al. (2012) Multiple versus single virus respiratory infections: viral load and clinical disease severity in hospitalized children. Influenza and Other Respiratory Viruses 6(1), 71–77. Background Molecular testing for viral pathogens has resulted in increasing detection of multiple viruses in respiratory secretions of ill children. The clinical impact of multiple virus infections on clinical presentation and outcome is unclear. Objectives To compare clinical characteristics and viral load between children with multiple virus versus single virus illnesses. Patients/methods Eight hundred and ninety‐three residual nasal wash samples from children treated for respiratory illness at Children’s Hospital, Seattle, from September 2003 to September 2004 were evaluated by quantitative PCR for respiratory syncytial virus (RSV), human metapneumovirus (hMPV), influenza (Flu), parainfluenza, adenoviruses, and coronaviruses (CoV). Illness severity and patient characteristics were abstracted from medical charts. Results Coinfections were identified in 103 (18%) of 566 virus‐positive samples. Adenovirus was most commonly detected in coinfections (52%), followed by CoV (50%). Illnesses with a single virus had increased risk of oxygen requirement (P = 0·02), extended hospital stays (P = 0·002), and admissions to the inpatient (P = 0·02) or intensive care units (P = 0·04). For Adv and PIV‐1, multiple virus illnesses had a significantly lower viral load (log10 copies/ml) than single virus illnesses (4·2 versus 5·6, P = 0·007 and 4·2 versus 6·9, P < 0·001, respectively). RSV, Flu‐A, PIV‐3, and hMPV viral loads were consistently high whether or not another virus was detected. Conclusions Illnesses with multiple virus detections were correlated with less severe disease. The relationship between viral load and multiple virus infections was virus specific, and this may serve as a way to differentiate viruses in multiple virus infections.
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DOI：
10.1086/652405
发表时间：
2010-06-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Martin ET;Fairchok MP;Kuypers J;Magaret A;Zerr DM;Wald A;Englund JA
通讯作者：
Englund JA
DOI：
10.1016/j.jcv.2004.03.018
发表时间：
2004-10
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Kuypers J;Wright N;Morrow R
通讯作者：
Morrow R
DOI：
10.1016/j.jcv.2004.11.023
发表时间：
2005-08
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Kuypers J;Wright N;Corey L;Morrow R
通讯作者：
Morrow R
急性呼吸道感染住院儿童的多病原体感染
影响因子：
4.8
作者：
Peng D;Zhao D;Liu J;Wang X;Yang K;Xicheng H;Li Y;Wang F
通讯作者：
Wang F
影响因子：
3.6
作者：
Wilkesmann, Anja;Schildgen, Oliver;Simon, Arne
通讯作者：
Simon, Arne