PROtein enriched MEDiterranean diet to combat undernutrition and promote healthy neuroCOGnitive ageing in older adults: The PROMED-COG consortium project.
PROtein enriched MEDiterranean diet to combat undernutrition and promote healthy neuroCOGnitive ageing in older adults: The PROMED-COG consortium project.
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DOI：
10.1111/nbu.12571
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发表时间：
2022-09
影响因子：
3.3
通讯作者：
McEvoy, Claire T.
中科院分区：
文献类型：
--
作者：
O'Neill, Roisin F.;Brennan, Lorraine;Prinelli, Federica;Sergi, Giuseppe;Trevisan, Caterina;De Groot, Lisette C. P. G. M.;Volkert, Dorothee;Maggi, Stefania;Noale, Marianna;Conti, Silvia;Adorni, Fulvio;Woodside, Jayne V.;McKinley, Michelle C.;McGuinness, Bernadette;Cardwell, Chris;McEvoy, Claire T.
痴呆症是一项重大的公共卫生挑战，因为它的发病率越来越高，并对老年人的残疾造成公认的影响。观察数据表明，体重减轻与痴呆症风险增加30%-40%相关，并且在诊断为认知障碍或痴呆症之前至少10年。尽管人们对痴呆症患者无意识体重减轻的机制知之甚少，但这为采取干预策略来抵消营养不良和延迟或预防痴呆症的发作提供了机会。本文提供了PROMED‐COG项目和相关工作包的概述。该项目旨在(1)加强流行病学证据，以更好地了解对抗营养不良对健康的神经认知衰老的潜在益处；(2)增加关于富含蛋白质的地中海饮食（PROMED）和体育锻炼之间平衡的科学知识，以预防营养不良和促进健康的神经认知衰老，并产生机制途径的数据；(3)促进欧洲营养和神经认知衰老研究的合作和能力建设；(4)制定公共和实践建议，以对抗营养不良，促进老年人健康的神经认知老化。研究结果将为营养不良在神经认知衰老中的作用，这种作用如何因性别、遗传风险和营养不良暴露的时间而不同，以及饮食和身体活动行为的改变如何减轻营养不良和神经变性的负担提供新的和关键的见解。研究结果将有助于为老年人饮食指南的政策和实践提供信息，并为行业提供基于食物的解决方案的发展，以防止营养不良。
Dementia is a major public health challenge owing to its increasing prevalence and recognised impact on disability among older adults. Observational data indicate that weight loss is associated with increased dementia risk of 30%–40% and precedes a diagnosis of cognitive impairment or dementia by at least one decade. Although relatively little is known about the mechanisms of unintentional weight loss in dementia, this provides a window of opportunity to intervene with strategies to counteract undernutrition and delay, or prevent, the onset of dementia. This article provides an overview of the PROMED‐COG project and associated work packages. The project aimes to (1) strengthen the epidemiologic evidence to better understand the potential benefits of combating undernutrition for healthy neurocognitive ageing; (2) increase scientific knowledge on the balance between a protein enriched Mediterranean diet (PROMED) and physical exercise to prevent undernutrition and promote healthy neurocognitive ageing, and generate data on mechanistic pathways; (3) stimulate collaboration and capacity building for nutrition and neurocognitive ageing research in Europe; and (4) develop public and practice recommendations to combat undernutrition and promote healthy neurocognitive ageing in older adults. Findings will provide new and critical insights into the role of undernutrition in neurocognitive ageing, how this role can differ by sex, genetic risk and timing of undernutrition exposure, and how modifications of dietary and physical activity behaviour can reduce the burden of undernutrition and neurodegeneration. The research outcomes will be useful to inform policy and practice about the dietary guidelines of older people and provide insight to industry for the development of food‐based solutions to prevent undernutrition.
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影响因子：
5.9
作者：
Ando T;Uchida K;Sugimoto T;Kimura A;Saji N;Niida S;Sakurai T
通讯作者：
Sakurai T
DOI：
10.1016/s0140-6736(17)31363-6
发表时间：
2017-12-16
期刊：
Lancet (London, England)
影响因子：
--
作者：
Livingston, Gill;Sommerlad, Andrew;Mukadam, Naaheed
通讯作者：
Mukadam, Naaheed
影响因子：
5.8
作者：
Allen, V.;Methven, L.;Gosney, M.
通讯作者：
Gosney, M.
影响因子：
6.3
作者：
Cederholm, T.;Bosaeus, I.;Singer, P.
通讯作者：
Singer, P.
DOI：
10.1177/1533317517705221
发表时间：
2017-09-01
影响因子：
3.4
作者：
de Sousa, Odete Vicente;Guerra, Rita Soares;Amaral, Teresa Freitas
通讯作者：
Amaral, Teresa Freitas