Efficacy of a synthetic biomimetic skin substitute of PLLA/gelatin nanofiber membrane in facilitating chronic cutaneous wound healing
Efficacy of a synthetic biomimetic skin substitute of PLLA/gelatin nanofiber membrane in facilitating chronic cutaneous wound healing
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PLLA/明胶纳米纤维膜合成仿生皮肤替代品促进慢性皮肤伤口愈合的功效
DOI：
10.1080/10667857.2019.1709286
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发表时间：
2020-12
影响因子：
3.1
通讯作者：
Zhu Lei
中科院分区：
文献类型：
--
作者：
He Ronghan;Wang Kun;Ren Jianhua;Zhang Wenhui;Wang Zhe;Deng Kunxue;Shi Yi;Luo Yuansen;Yuan Yuyu;Xu Tao;Zhu Lei
摘要：本研究旨在确定聚l -丙交酯/明胶纳米纤维膜合成仿生皮肤替代品促进慢性皮肤伤口愈合的效果。对材料的物理性能和生物学特性进行了评价。临床应用进一步证实了该方法的安全性和有效性。结果表明，纳米孔的平均直径为0.65 μm。平均接触角为80.39°，平均抗拉强度为4.42±0.43 MPa。培养第7天，成纤维细胞和单核细胞的增殖明显改善。此外，细菌在代用品上的粘附也降低了。在临床病例研究中，伤口完全愈合率为93.3%，再手术率为6.7%。因此，这项技术提出了一种有趣的可能的治疗方式，可以缓解疼痛，减少慢性伤口治疗中再次手术的负担。
ABSTRACT This research was set up to determine the efficacy of a synthetic biomimetic skin substitute of poly-L-lactide (PLLA)/gelatin nanofiber membrane in facilitating chronic cutaneous wound healing. The material physical properties and biological characteristics were evaluated. The safety and effectiveness were further confirmed by clinical applications. Results indicated that the average diameter of the nano pores in the biomimetic substitute was 0.65 μm. The mean contact angle was 80.39°, and the average tensile strength was 4.42 ± 0.43 MPa. The proliferation of fibroblasts and monocytes was significantly improved at day 7 cultured on the substitute. Moreover, the bacterial adhesion on the substitute was decreased. In the clinical case study, the percentage of complete wound healing was 93.3%, and the rate of reoperation was 6.7%. Thus, this technology presents an intriguing possible therapeutic modality that provides pain relief and diminishes the burden of reoperation in the setting of chronic wound management.
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影响因子：
3.6
作者：
Barker JC;Khansa I;Gordillo GM
通讯作者：
Gordillo GM
影响因子：
2.9
作者：
Greaves, Nicholas S.;Iqbal, Syed A.;Bayat, Ardeshir
通讯作者：
Bayat, Ardeshir
影响因子：
--
作者：
MOFFATT, CJ;FRANKS, PJ;MCCOLLUM, CN
通讯作者：
MCCOLLUM, CN
影响因子：
3.1
作者：
Bilgic, Melike Bayindir;Lacin, Nelisa Turkoglu;Mansuroglu, Banu
通讯作者：
Mansuroglu, Banu
影响因子：
1.4
作者：
Gibran, Nicole S.;Boyce, Steven;Greenhalgh, David G.
通讯作者：
Greenhalgh, David G.