Effect of long-term voluntary exercise and energy restriction on bone mineral density in mature female rats
Effect of long-term voluntary exercise and energy restriction on bone mineral density in mature female rats
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长期自主运动和能量限制对成年雌性大鼠骨密度的影响
DOI：
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Y. Ishimi
中科院分区：
文献类型：
--
作者：
Kaoru Yanaka;M. Higuchi;Y. Ishimi
女运动员三联症是一种导致饮食失调、闭经和骨质疏松症的综合征。导致女运动员骨量减少的病理生理机制是低能量和功能性下丘脑闭经。本研究的目的是建立一种类似于女运动员骨质疏松的动物模型。研究了长期能量限制对自愿轮跑雌性大鼠骨密度、17β-雌二醇(E_2)和黄体生成素(L H)水平的影响。14只8周龄雌性SD大鼠随机分为2组：跑步(Run)组和安静(SED)组。18周龄时，将跑步组进一步随机分为2组：自由跑饲组(RC组)和限跑饲养组(RR组)。实验后24周，RR组大鼠的骨密度和血浆LH水平显著低于RC组和SED组(p<；0.05)。RR组血浆E_2水平显著低于SED组(P<；0.05)。本研究表明，长期的能量限制加上自主车轮运行，对卵巢完整的雌性大鼠表现出低骨量。此外，在这个模型中观察到的明显的内分泌特征表明，自愿运动的能量限制干扰了下丘脑-垂体-卵巢轴。这可能为生殖系统功能障碍所致能量受限的运动女性骨质疏松症的发生发展提供一个模型。
The female athlete triad is a syndrome that leads to disordered eating, amenorrhea, and osteoporosis. The pathophysiologic mechanisms that lead to reduced bone mass in female athletes are low energy and functional hypothalamic amenorrhea. The aim of the present study was to establish an animal model of osteoporosis, which is similar to the osteoporosis seen in female athletes. We investigated the effects of long-term energy restriction on bone mineral density (BMD), and the levels of 17β-estradiol (E2) and luteinizing hormone (LH) in voluntary wheel-running female rats. Fourteen female Sprague–Dawley rats (8 weeks old) were randomly categorized into 2 groups: running (RUN) group and sedentary (SED) group. At 18 weeks of age, the rats in the RUN group were further randomly divided into 2 groups: runningad libitum feeding group (RC group) or running-restricted feeding group (RR group). Twentyfour weeks after the experimental period, the RR group showed significantly lower BMD and plasma LH levels than the RC and SED groups (p < 0.05). Plasma E2 levels in the RR group were significantly lower than that in the SED group (p < 0.05). The present study indicated that long-term energy restriction with voluntary wheel running exhibited low bone mass in female rats with intact ovaries. Furthermore, the distinct endocrine profiles observed in this model suggest that energy restriction with voluntary exercise disturbs the hypothalamic-pituitary-ovarian axis. This may establish a model for the development of osteoporosis in the exercising human female with energy restriction, caused by dysfunction of the reproductive system.
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运动后大鼠骨矿化模式与年龄相关的差异。
DOI：
10.1093/geronj/41.4.445
发表时间：
1986
期刊：
Journal of gerontology
影响因子：
--
作者：
McDonald,R;Hegenauer,J;Saltman,P
通讯作者：
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DOI：
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发表时间：
2001
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
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作者：
Williams,NI;Helmreich,DL;Parfitt,DB;Caston-Balderrama,A;Cameron,JL
通讯作者：
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DOI：
10.1210/jcem.80.12.8530611
发表时间：
1995-12
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
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作者：
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通讯作者：
S. Grinspoon;H. Baum;V. Kim;C. Coggins;A. Klibanski
DOI：
10.1093/ajcn/73.2.347
发表时间：
2001-02
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
T. Ricci;Steven B. Heymsfield;Richard N. Pierson;Theodore Stahl;H. Chowdhury;S. Shapses
通讯作者：
T. Ricci;Steven B. Heymsfield;Richard N. Pierson;Theodore Stahl;H. Chowdhury;S. Shapses
低剂量甲状旁腺激素可维持成年雄性大鼠体重快速减轻期间的正常骨形成。
影响因子：
4.1
作者：
Turner,RussellT;Iwaniec,UrszulaT
通讯作者：
Iwaniec,UrszulaT