Regulating Stem Cell Secretome Using Injectable Hydrogels with In Situ Network Formation.

Regulating Stem Cell Secretome Using Injectable Hydrogels with In Situ Network Formation.
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DOI:
10.1002/adhm.201600497
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发表时间:
2016-11
影响因子:
10
通讯作者:
Heilshorn SC
Heilshorn SC
中科院分区:
工程技术1区
文献类型:
--
作者:
Cai L;Dewi RE;Goldstone AB;Cohen JE;Steele AN;Woo YJ;Heilshorn SC

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A family of Shear-thinning Hydrogels for Injectable Encapsulation and Long-term Delivery (SHIELD) has been designed and synthesized with controlled in situ stiffening properties to regulate the stem cell secretome. We demonstrate that SHIELD with an intermediate stiffness (200 – 400 Pa) could significantly promote the angiogenic potential of human adipose-derived stem cells (hASCs).
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