Comparison of the Characteristics and Prognosis Between Very Young Women and Older Women With Breast Cancer: A Multi-Institutional Report From China.
Comparison of the Characteristics and Prognosis Between Very Young Women and Older Women With Breast Cancer: A Multi-Institutional Report From China.
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DOI：
10.3389/fonc.2022.783487
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发表时间：
2022
影响因子：
4.7
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Yang Y;Wei W;Jin L;He H;Wei M;Shen S;Pi H;Liu Z;Li H;Liu J
我们对非常年轻女性（≤35岁）乳腺癌的了解仍然有限。我们的目的是评估这些年轻患者与35岁以上患者的临床病理特征、分子亚型、治疗分布和预后。我们回顾性分析了2008年1月1日至2018年12月31日在中国三家学术医院治疗的非转移性女性乳腺癌病例。局部无复发生存期（LRFS）、无病生存期（DFS）和总生存期（OS）在不同年龄组之间进行比较，并根据不同的分子亚型进行分层。共有11,671名妇女符合最终分析的条件，其中1207名妇女（10.3%）发病年龄≤35岁。非常年轻的乳腺癌女性多为单身或无孩子，疾病级别较高，肿瘤淋巴血管浸润（LVI）和三阴性亚型的概率更高，接受乳房肿瘤切除术、化疗（尤其是蒽环类和紫杉醇类化疗）、内分泌治疗加卵巢功能抑制（OFS）、抗her2治疗和/或放疗的比例高于老年女性（均P < 0.05）。在所有年龄组中，非常年轻的女性的5年LRFS和DFS最低（P < 0.001）。当按分子亚型分层时，非常年轻的女性与35~50岁组或50岁组的女性相比，激素受体阳性(HR+)/人表皮生长因子受体2阴性（HER2 -）亚型的预后最差，包括LRFS、DFS和OS（均P < 0.05）。在LRFS和DFS方面，多变量分析显示不同年龄组的结果相似。我们的研究表明，与老年患者相比，非常年轻的女性乳腺癌患者肿瘤级别更高，肿瘤中LVI的可能性更大，三阴性亚型更多。他们的生存结果不太有利，特别是对于HR+/HER2 -亚型患者。
Our understanding of breast cancer in very young women (≤35 years old) remains limited. We aimed to assess the clinicopathological characteristics, molecular subtype, and treatment distribution and prognosis of these young patients compared with patients over 35 years. We retrospectively analyzed non-metastatic female breast cancer cases treated at three Chinese academic hospitals between January 1, 2008, and December 31, 2018. Local recurrence-free survival (LRFS), disease-free survival (DFS), and overall survival (OS) were compared between different age groups and stratified with distinct molecular subtypes. A total of 11,671 women were eligible for the final analyses, and 1,207 women (10.3%) were ≤35 years at disease onset. Very young breast cancer women were more likely to be single or childless, have higher-grade disease, have more probability of lymphovascular invasion (LVI) in tumor and triple-negative subtype, and be treated by lumpectomy, chemotherapy especially more anthracycline- and paclitaxel-based chemotherapy, endocrine therapy plus ovarian function suppression (OFS), anti-HER2 therapy, and/or radiotherapy than older women (P < 0.05 for all). Very young women had the lowest 5-year LRFS and DFS among all age groups (P < 0.001 for all). When stratified by molecular subtype, very young women had the worst outcomes vs. women from the 35~50-year-old group or those from >50-year-old group for hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2−) subtype, including LRFS, DFS, and OS (P < 0.05 for all). In terms of LRFS and DFS, multivariate analyses showed similar results among the different age groups. Our study demonstrated that very young women with breast cancer had higher-grade tumors, more probability of LVI in tumor, and more triple-negative subtype, when compared with older patients. They had less favorable survival outcomes, especially for patients with the HR+/HER2− subtype.
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影响因子：
11.5
作者：
Azim, Hatem A., Jr.;Michiels, Stefan;Loi, Sherene
通讯作者：
Loi, Sherene
为绝经前乳腺癌调整辅助内分泌疗法。
DOI：
10.1056/nejmoa1803164
发表时间：
2018-07-12
期刊：
The New England journal of medicine
影响因子：
--
作者：
Francis PA;Pagani O;Fleming GF;Walley BA;Colleoni M;Láng I;Gómez HL;Tondini C;Ciruelos E;Burstein HJ;Bonnefoi HR;Bellet M;Martino S;Geyer CE Jr;Goetz MP;Stearns V;Pinotti G;Puglisi F;Spazzapan S;Climent MA;Pavesi L;Ruhstaller T;Davidson NE;Coleman R;Debled M;Buchholz S;Ingle JN;Winer EP;Maibach R;Rabaglio-Poretti M;Ruepp B;Di Leo A;Coates AS;Gelber RD;Goldhirsch A;Regan MM;SOFT and TEXT Investigators and the International Breast Cancer Study Group
通讯作者：
SOFT and TEXT Investigators and the International Breast Cancer Study Group
影响因子：
3.8
作者：
Murphy, Caitlin C.;Bartholomew, L. Kay;Carpentier, Melissa Y.;Bluethmann, Shirley M.;Vernon, Sally W.
通讯作者：
Vernon, Sally W.
DOI：
10.3760/cma.j.issn.0253-9624.2018.06.003
发表时间：
2018-06-06
影响因子：
--
作者：
Sun, K X;Zheng, R S;He, J
通讯作者：
He, J
患者年龄是否会影响诊断环境中 ACR BI-RADS 超声类别 4 和 5 的 PPV3？
影响因子：
5.9
作者：
Hu, Yue;Yang, Yaping;Su, Fengxi
通讯作者：
Su, Fengxi