Association of citrulline concentration at birth with lower respiratory tract infection in infancy: Findings from a multi-site birth cohort study.
Association of citrulline concentration at birth with lower respiratory tract infection in infancy: Findings from a multi-site birth cohort study.
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DOI：
10.3389/fped.2022.979777
复制
发表时间：
2022
影响因子：
2.6
通讯作者：
ECHO-CREW investigators
中科院分区：
文献类型：
--
作者：
Snyder, Brittney M.;Gebretsadik, Tebeb;Turi, Kedir N.;McKennan, Christopher;Havstad, Suzanne;Jackson, Daniel J.;Ober, Carole;Lynch, Susan;McCauley, Kathryn;Seroogy, Christine M.;Zoratti, Edward M.;Khurana Hershey, Gurjit K.;Berdnikovs, Sergejs;Cunningham, Gary;Summar, Marshall L.;Gern, James E.;Hartert, Tina V.;ECHO-CREW investigators
评估新生儿代谢状态与随后呼吸道感染严重程度的相关性可能为感染发病机制提供重要见解。在这项多中心出生队列研究中，我们在发现队列中确定了与生命第一年下呼吸道感染（LRTI）相关的新生儿代谢物，并在两个独立队列中进行了复制评估。瓜氨酸浓度升高与LRTI几率降低相关（发现队列：aOR 0.83 [95% CI 0.70-0.99]，p = 0.04;复制队列：aOR 0.58 [95% CI 0.28-1.22]，p = 0.15）。虽然我们的研究结果需要进一步复制和研究作用机制，但它们确定了LRTI预防和治疗的新靶点。
Assessing the association of the newborn metabolic state with severity of subsequent respiratory tract infection may provide important insights on infection pathogenesis. In this multi-site birth cohort study, we identified newborn metabolites associated with lower respiratory tract infection (LRTI) in the first year of life in a discovery cohort and assessed for replication in two independent cohorts. Increased citrulline concentration was associated with decreased odds of LRTI (discovery cohort: aOR 0.83 [95% CI 0.70–0.99], p = 0.04; replication cohorts: aOR 0.58 [95% CI 0.28–1.22], p = 0.15). While our findings require further replication and investigation of mechanisms of action, they identify a novel target for LRTI prevention and treatment.
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影响因子：
30.3
作者：
Qualls JE;Subramanian C;Rafi W;Smith AM;Balouzian L;DeFreitas AA;Shirey KA;Reutterer B;Kernbauer E;Stockinger S;Decker T;Miyairi I;Vogel SN;Salgame P;Rock CO;Murray PJ
通讯作者：
Murray PJ
影响因子：
7.3
作者：
Lee, Yi-Chen;Su, Yu-Tsun;Yu, Hong-Ren
通讯作者：
Yu, Hong-Ren
DOI：
10.1016/s0140-6736(22)00478-0
发表时间：
2022-05-28
期刊：
Lancet (London, England)
影响因子：
--
作者：
Li Y;Wang X;Blau DM;Caballero MT;Feikin DR;Gill CJ;Madhi SA;Omer SB;Simões EAF;Campbell H;Pariente AB;Bardach D;Bassat Q;Casalegno JS;Chakhunashvili G;Crawford N;Danilenko D;Do LAH;Echavarria M;Gentile A;Gordon A;Heikkinen T;Huang QS;Jullien S;Krishnan A;Lopez EL;Markić J;Mira-Iglesias A;Moore HC;Moyes J;Mwananyanda L;Nokes DJ;Noordeen F;Obodai E;Palani N;Romero C;Salimi V;Satav A;Seo E;Shchomak Z;Singleton R;Stolyarov K;Stoszek SK;von Gottberg A;Wurzel D;Yoshida LM;Yung CF;Zar HJ;Respiratory Virus Global Epidemiology Network;Nair H;RESCEU investigators
通讯作者：
RESCEU investigators
影响因子：
8
作者：
Carroll, Kecia N.;Gebretsadik, Tebeb;Hartert, Tina V.
通讯作者：
Hartert, Tina V.
影响因子：
8
作者：
Breese, Caroline;Weinberg, Geoffrey A.;Iwane, Marika K.
通讯作者：
Iwane, Marika K.