The puzzle of sex, gender and Alzheimer’s disease: Why are women more often affected than men?
The puzzle of sex, gender and Alzheimer’s disease: Why are women more often affected than men?
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DOI：
10.1177/1745506518817995
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发表时间：
2018-12-26
期刊：
影响因子：
--
通讯作者：
Tierney MC
中科院分区：
文献类型：
--
作者：
Andrew MK;Tierney MC
有令人印象深刻的差异的发病率，患病率和经验的妇女和男子与阿尔茨海默氏病（AD）。值得注意的是，三分之二的AD患者（最常见的痴呆症）是女性。我们的目标是提供一个基于文献的框架，以了解这些性别和性别差异的AD。我们进行了一个叙述性的审查，以检查性别和性别对AD的影响。我们提出了一个框架，以了解为什么这些性别和性别差异存在于AD。这包括寿命的影响（妇女比男子寿命长）、生物差异（荷尔蒙差异、表观遗传学和虚弱）、认知能力的差异（妇女和男子在某些认知测试中的表现往往不同）以及性别社会角色和机会（教育和职业机会、退休后的职能角色）。我们的审查清楚地表明，这些性别和性别差异的复杂的相互作用和变化在每一个。鉴于AD中这些重要的性别差异，我们提出了建议和步骤，描述了在痴呆症诊断和管理以及痴呆症研究的设计和实施中应如何考虑性别和性别，包括痴呆症护理干预措施和模型的研究。
There are impressive differences in the incidence, prevalence and experience of women and men with Alzheimer’s Disease (AD). Notably, two-thirds of those with AD, the most common form of dementia, are women. Our objective was to provide a literature-based framework to understand these sex and gender differences in AD. We conducted a narrative review to examine sex and gender influences on AD. We present a framework to understanding why these sex and gender differences exist in AD. This includes the influence of longevity (women live longer than men), biological differences (hormonal differences, epigenetics and frailty), differences in cognitive performance (women and men tend to perform differently on some cognitive tests), and gendered social roles and opportunities (educational and occupational opportunities, functional roles post-retirement). Our review clearly indicates the complex interaction of these sex and gender differences and variability within each. Given these important sex and gender differences in AD, we provide recommendations and steps forward describing how both sex and gender should be considered in dementia diagnosis and management and in the design and implementation of dementia research, including studies of caregiving interventions and models of dementia care.
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影响因子：
4.8
作者：
Gaignard P;Liere P;Thérond P;Schumacher M;Slama A;Guennoun R
通讯作者：
Guennoun R
影响因子：
4
作者：
Berezuk, Courtney;Zakzanis, Konstantine K.;Black, Sandra E.
通讯作者：
Black, Sandra E.
影响因子：
--
作者：
Gao, S;Hendrie, HC;Hall, KS
通讯作者：
Hall, KS
DOI：
10.1016/j.bbi.2017.05.010
发表时间：
2017-08
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Bilbo SD
通讯作者：
Bilbo SD
影响因子：
9.8
作者：
Fields JA;Garovic VD;Mielke MM;Kantarci K;Jayachandran M;White WM;Butts AM;Graff-Radford J;Lahr BD;Bailey KR;Miller VM
通讯作者：
Miller VM