Human Gut Microbiome-Based Knowledgebase as a Biomarker Screening Tool to Improve the Predicted Probability for Colorectal Cancer.
Human Gut Microbiome-Based Knowledgebase as a Biomarker Screening Tool to Improve the Predicted Probability for Colorectal Cancer.
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DOI：
10.3389/fmicb.2020.596027
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发表时间：
2020
影响因子：
5.2
通讯作者：
Chen P
中科院分区：
文献类型：
--
作者：
Zhou Z;Ge S;Li Y;Ma W;Liu Y;Hu S;Zhang R;Ma Y;Du K;Syed A;Chen P
结直肠癌（Colorectal cancer，CRC）是一种常见的临床恶性肿瘤，在全球癌症死亡率中居第四位。已知一些微生物有助于腺瘤-癌转变并具有诊断潜力。高通量测序技术和功能研究的进展为肠道微生物组的景观及其组分在致癌作用中的基本作用提供了重要见解。整合分散的知识对未来的进步是非常有益的。本研究采用文献回顾和信息提取的方法，旨在整合现有的数据资源，促进比较研究。编译了人类CRC微生物组的知识库以促进对诊断的理解，并基于统计和系统发育分析评估了CRC微生物的全局特征、样本类型、算法、差异微生物和各种标志物组及其诊断性能。最后，对当前的换生灵问题进行了展望，并提出了解决策略，为今后的研究指明了方向。这种类型的数据整合策略为相关信息的查询和比较提供了一个有效的平台，为进一步研究CRC相关微生物和探索促进临床转化的因素提供了工具（可在：http://gsbios.com/index/experimental/dts_ mben？id=1）。
Colorectal cancer (CRC) is a common clinical malignancy globally ranked as the fourth leading cause of cancer mortality. Some microbes are known to contribute to adenoma-carcinoma transition and possess diagnostic potential. Advances in high-throughput sequencing technology and functional studies have provided significant insights into the landscape of the gut microbiome and the fundamental roles of its components in carcinogenesis. Integration of scattered knowledge is highly beneficial for future progress. In this study, literature review and information extraction were performed, with the aim of integrating the available data resources and facilitating comparative research. A knowledgebase of the human CRC microbiome was compiled to facilitate understanding of diagnosis, and the global signatures of CRC microbes, sample types, algorithms, differential microorganisms and various panels of markers plus their diagnostic performance were evaluated based on statistical and phylogenetic analyses. Additionally, prospects about current changelings and solution strategies were outlined for identifying future research directions. This type of data integration strategy presents an effective platform for inquiry and comparison of relevant information, providing a tool for further study about CRC-related microbes and exploration of factors promoting clinical transformation (available at: http://gsbios.com/index/experimental/dts_ mben?id=1).
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影响因子：
16.6
作者：
Duvallet C;Gibbons SM;Gurry T;Irizarry RA;Alm EJ
通讯作者：
Alm EJ
影响因子：
30.3
作者：
Chung L;Thiele Orberg E;Geis AL;Chan JL;Fu K;DeStefano Shields CE;Dejea CM;Fathi P;Chen J;Finard BB;Tam AJ;McAllister F;Fan H;Wu X;Ganguly S;Lebid A;Metz P;Van Meerbeke SW;Huso DL;Wick EC;Pardoll DM;Wan F;Wu S;Sears CL;Housseau F
通讯作者：
Housseau F
影响因子：
24.5
作者：
Flemer B;Lynch DB;Brown JM;Jeffery IB;Ryan FJ;Claesson MJ;O'Riordain M;Shanahan F;O'Toole PW
通讯作者：
O'Toole PW
DOI：
10.1109/tcbb.2018.2870124
发表时间：
2020-03-01
影响因子：
4.5
作者：
Arabameri, Abazar;Asemani, Davud;Teymourpour, Pegah
通讯作者：
Teymourpour, Pegah
影响因子：
7
作者：
Castellarin, Mauro;Warren, Rene L.;Holt, Robert A.
通讯作者：
Holt, Robert A.