Firmicutes in Gut Microbiota Correlate with Blood Testosterone Levels in Elderly Men.
Firmicutes in Gut Microbiota Correlate with Blood Testosterone Levels in Elderly Men.
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老年男性肠道菌群中的厚壁菌门与血液睾酮水平相关。
DOI：
10.5534/wjmh.210190
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发表时间：
2022-07
期刊：
影响因子：
--
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中科院分区：
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在男性中，睾丸激素水平与各种疾病有关。近年来，肠道微生物衍生化合物对宿主代谢的影响越来越明显，一些肠道细菌可能参与了睾酮的代谢。在这项研究中，我们研究了日本老年男性的睾丸激素水平和肠道微生物区系之间的关系。我们收集了怀疑患有前列腺癌的日本男性受试者的样本，并接受了前列腺活检，并排除了活检阳性的患者，以避免前列腺癌对肠道微生物区系的影响。在我们的研究中，总共有54例活检结果为阴性的日本男性。对直肠拭子中提取的细菌DNA进行16S rRNA基因测序，分析肠道微生物区系。根据血清睾酮水平(高于或低于3.5 ng/m L)比较两组的肠道微生物区系组成。队列的中位年龄为71岁，四分位数范围为67至73岁。我们没有观察到α或β多样性的显著差异，但高睾酮组的一些细菌(梭状芽胞杆菌、Turicibacter和Gemella)有所增加。血清睾酮水平与非米非司酮的相对用量呈正相关(RS=0.3323，p=0.0141)，非米米特用量影响血清睾酮水平不受宿主因素(年龄、体重指数、甘油三酯和总胆固醇；β=0.770，p=0.0396)的影响。在老年男性中，一些肠道细菌与睾丸激素水平有关。因此，肠道微生物区系可能会影响老年男性的睾酮代谢。
In males, testosterone levels have been implicated in various diseases. Recently, the influence of gut microbial-derived compounds on host metabolism has become evident, and it has been suggested that some gut bacteria may be involved in testosterone metabolism. In the present study, we examined the relationship between testosterone levels and gut microbiota in elderly Japanese men. We collected samples from Japanese male subjects suspected of having prostate cancer and underwent prostate biopsies and excluded patients with positive biopsies to avoid the effect of prostate cancer on the gut microbiota. In total, 54 Japanese males with negative biopsy results were included in our study. The gut microbiota was analyzed by 16S rRNA gene sequencing of bacterial DNA extracted from rectal swabs. Gut microbiota compositions were compared between the two groups according to the level of serum testosterone (above or below 3.5 ng/mL). The median age of the cohort was 71 years, and the quartile range was 67 to 73 years. We observed no significant difference in alpha or beta diversity, but some bacteria belonging to the phylum Firmicutes (Clostridiales, Turicibacter, and Gemella) were increased in the high testosterone group. Serum testosterone levels positively correlated with the relative amount of Firmicutes (rS=0.3323, p=0.0141), and the amount of Firmicutes affected serum testosterone levels independent of host factors (age, body mass index, triglyceride, and total cholesterol; β=0.770, p=0.0396). Some intestinal bacteria belonging to the phylum Firmicutes were associated with testosterone levels in elderly males. Therefore, the gut microbiota could affect testosterone metabolism in elderly males.
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影响因子：
2.4
作者：
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通讯作者：
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影响因子：
56.9
作者：
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通讯作者：
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影响因子：
56.9
作者：
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通讯作者：
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影响因子：
4.2
作者：
Lee J;Yang W;Hostetler A;Schultz N;Suckow MA;Stewart KL;Kim DD;Kim HS
通讯作者：
Kim HS
DOI：
10.1093/dnares/dsw002
发表时间：
2016-04
期刊：
DNA research : an international journal for rapid publication of reports on genes and genomes
影响因子：
--
作者：
Nishijima S;Suda W;Oshima K;Kim SW;Hirose Y;Morita H;Hattori M
通讯作者：
Hattori M