Does degree of gyrification underlie the phenotypic and genetic associations between cortical surface area and cognitive ability?
Does degree of gyrification underlie the phenotypic and genetic associations between cortical surface area and cognitive ability?
复制标题
DOI：
10.1016/j.neuroimage.2014.11.040
复制
发表时间：
2015-02-01
期刊：
影响因子：
5.7
通讯作者：
Kremen WS
中科院分区：
文献类型：
--
作者：
Docherty AR;Hagler DJ Jr;Panizzon MS;Neale MC;Eyler LT;Fennema-Notestine C;Franz CE;Jak A;Lyons MJ;Rinker DA;Thompson WK;Tsuang MT;Dale AM;Kremen WS
全球皮质大小和一般认知能力（GCA）之间的表型和遗传关系似乎是由表面积（SA）而不是皮质厚度（CT）驱动的。回旋（皮质折叠）是皮质的一个重要特性，有助于增加有限空间内的SA，并且还可以通过减少区域之间的距离来改善连通性。因此，回旋可能是什么的SA-GCA关系的基础。在以前的表型研究中，三维旋转指数（3DGI）与认知能力呈正相关，与轻度认知障碍、阿尔茨海默病和影响认知的精神疾病呈负相关。然而，3DGI和SA与GCA的差异遗传关联仍不清楚。我们在一个大样本的成年男性双胞胎（N = 512）中研究了3DGI的遗传力，以及3DGI与SA和GCA的表型、遗传和环境相关性。近85%的变异在3DGI是由于基因，和3DGI有很强的表型和遗传关联SA。3DGI和总SA均与GCA呈正相关。然而，在控制3DGI后，SA-GCA相关性仍然显著，但反之则不显著。SA和GCA之间也存在显著的遗传协方差，但3DGI和GCA之间不存在显著的遗传协方差。因此，尽管3DGI和SA之间存在表型和遗传关联，但我们的结果并不支持回转是SA和GCA之间关联的基础的假设。
The phenotypic and genetic relationship between global cortical size and general cognitive ability (GCA) appears to be driven by surface area (SA) and not cortical thickness (CT). Gyrification (cortical folding) is an important property of the cortex that helps to increase SA within a finite space, and may also improve connectivity by reducing distance between regions. Hence, gyrification may be what underlies the SA-GCA relationship. In previous phenotypic studies, a 3-dimensional gyrification index (3DGI) has been positively associated with cognitive ability and negatively associated with mild cognitive impairment, Alzheimer’s disease, and psychiatric disorders affecting cognition. However, the differential genetic associations of 3DGI and SA with GCA are still unclear. We examined the heritability of 3DGI, and the phenotypic, genetic, and environmental associations of 3DGI with SA and GCA in a large sample of adult male twins (N = 512). Nearly 85% of the variance in 3DGI was due to genes, and 3DGI had a strong phenotypic and genetic association with SA. Both 3DGI and total SA had positive phenotypic correlations with GCA. However, the SA-GCA correlation remained significant after controlling for 3DGI, but not the other way around. There was also significant genetic covariance between SA and GCA, but not between 3DGI and GCA. Thus, despite the phenotypic and genetic associations between 3DGI and SA, our results do not support the hypothesis that gyrification underlies the association between SA and GCA.
登录
查看更多内容
影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
5.7
作者：
Eisenberg, Daniel Paul;Jabbi, Mbemba;Berman, Karen Faith
通讯作者：
Berman, Karen Faith
影响因子：
3
作者：
Boker S;Neale M;Maes H;Wilde M;Spiegel M;Brick T;Spies J;Estabrook R;Kenny S;Bates T;Mehta P;Fox J
通讯作者：
Fox J
影响因子：
0.9
作者：
Kremen, William S.;Franz, Carol E.;Lyons, Michael J.
通讯作者：
Lyons, Michael J.
影响因子：
4.3
作者：
Palaniyappan, Lena;Liddle, Peter F.
通讯作者：
Liddle, Peter F.