Multifaceted roles of WRKY transcription factors in abiotic stress and flavonoid biosynthesis.

Multifaceted roles of WRKY transcription factors in abiotic stress and flavonoid biosynthesis.
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DOI:
10.3389/fpls.2023.1303667
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发表时间:
2023
影响因子:
5.6
通讯作者:
--
中科院分区:
生物学2区
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--
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日益严重的生物和非生物压力正在严重阻碍主要作物的生长和产量,威胁全球粮食安全。WRKY转录因子是维管植物中最大的一类调节因子,在逆境胁迫下调控类黄酮的合成起着重要作用。WRKYs通过结合靶启动子中的主要W盒顺式元件(TGACCA/T)来调节多种信号传导途径。在这篇综述中,我们优化了现有的WRKY系统发育树,将额外的植物物种与WRKY蛋白参与胁迫耐受性和类黄酮调控。基于改进的框架和记录的结果,我们的目标是推导出不同的WRKY亚家族管理特定的应激反应和类黄酮代谢的统一主题。这些分析将产生实验验证的假设,关于假定的功能,未表征WRKY同系物在调整类黄酮的积累,以提高压力恢复力。
Increasing biotic and abiotic stresses are seriously impeding the growth and yield of staple crops and threatening global food security. As one of the largest classes of regulators in vascular plants, WRKY transcription factors play critical roles governing flavonoid biosynthesis during stress responses. By binding major W-box cis-elements (TGACCA/T) in target promoters, WRKYs modulate diverse signaling pathways. In this review, we optimized existing WRKY phylogenetic trees by incorporating additional plant species with WRKY proteins implicated in stress tolerance and flavonoid regulation. Based on the improved frameworks and documented results, we aim to deduce unifying themes of distinct WRKY subfamilies governing specific stress responses and flavonoid metabolism. These analyses will generate experimentally testable hypotheses regarding the putative functions of uncharacterized WRKY homologs in tuning flavonoid accumulation to enhance stress resilience.
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