Chitosan Modulates Inflammatory Responses in Rats Infected with Enterotoxigenic Escherichia coli.
Chitosan Modulates Inflammatory Responses in Rats Infected with Enterotoxigenic Escherichia coli.
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DOI：
10.1155/2016/7432845
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发表时间：
2016
影响因子：
4.6
通讯作者：
Fang J
中科院分区：
文献类型：
--
作者：
Liu G;Chen S;Guan G;Tan J;Al-Dhabi NA;Wang H;Duraipandiyan V;Fang J
本研究旨在探讨膳食几丁糖(COS)对小鼠胃肠道病原菌抵抗力的影响。对照组给予基础饲料，干预组给予基础饲料中添加300 mg/KgCOS2周。两周后，喂食补充饲料的小鼠体重较轻。然后给小鼠灌胃肠毒素大肠杆菌，每只小鼠接种108CFU的 菌落。感染后第7天，COS组空肠和粪便细菌载量明显低于对照组。此外，给予黄曲霉毒素饲料的小鼠白介素1β、白介素6、白介素17、白介素18和肿瘤坏死因子α的基因和蛋白水平显著降低，空肠Toll样受体4的产生也受到抑制。这些结果表明，干预措施影响了炎症反应，控制了大肠杆菌感染。
This study aims to investigate the effects of dietary chitosan (COS) on gastrointestinal pathogen resistance in mice model. For two weeks, a control group of ICR mice received a basal diet whilst the intervention group received the basal diet supplemented with 300 mg/kg COS. After two weeks, the mice fed the supplemented diet had a lower body weight. Then enterotoxigenic Escherichia coli (E. coli) was administered to the mice through oral gavage, with each mouse receiving 108 CFU. At day 7 after infection, the bacterial load in the jejunum and faeces was significantly lower in the COS group than that in the control group. Moreover, the mRNA and protein levels of IL-1β, IL-6, IL-17, IL-18, and TNF-α were significantly lower in the group of mice receiving the COS diet; also the jejunal production of toll-like receptor-4 (TLR-4) was suppressed in the COS group. These results indicate the intervention influenced inflammation and controlled E. coli infection.
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干扰素 Tau 影响小鼠肠道微生物群和 IL-17 的表达
影响因子：
4.6
作者：
Ren W;Chen S;Zhang L;Liu G;Hussain T;Hao X;Yin J;Duan J;Tan B;Wu G;Bazer FW;Yin Y
通讯作者：
Yin Y
小鼠膳食精氨酸补充剂改变微生物群并激活肠道先天免疫
影响因子：
4.2
作者：
Ren, Wenkai;Chen, Shuai;Wu, Guoyao
通讯作者：
Wu, Guoyao
影响因子：
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作者：
Kim JG;Jo SH;Ha KS;Kim SC;Kim YC;Apostolidis E;Kwon YI
通讯作者：
Kwon YI
DOI：
10.1128/genomea.00088-16
发表时间：
2016-03-01
期刊：
GENOME ANNOUNCEMENTS
影响因子：
--
作者：
Liu, Hongbin;Song, Li;Yu, Lei
通讯作者：
Yu, Lei
影响因子：
4.7
作者：
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通讯作者：
Zhou, Zhigang