Prenatal Exposure to the Phytoestrogen Daidzein Resulted in Persistent Changes in Ovarian Surface Epithelial Cell Height, Folliculogenesis, and Estrus Phase Length in Adult Sprague-Dawley Rat Offspring
Prenatal Exposure to the Phytoestrogen Daidzein Resulted in Persistent Changes in Ovarian Surface Epithelial Cell Height, Folliculogenesis, and Estrus Phase Length in Adult Sprague-Dawley Rat Offspring
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产前暴露于植物雌激素大豆苷元导致成年斯普拉格-道利大鼠后代卵巢表面上皮细胞高度、卵泡发生和发情期长度的持续变化
DOI：
10.1080/15287394.2015.1006711
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
I. Chahoud
中科院分区：
文献类型：
--
作者：
C. Talsness;K. Grote;S. Kuriyama;Kenia M Presibella;A. Sterner;K. Poça;I. Chahoud
大豆苷元（DZ）是一种可能干扰雌激素信号的异黄酮，存在于豆制品中，由于据称对心血管和骨骼系统有益以及潜在的抗肿瘤特性而受到欢迎。然而，植物雌激素的摄入与许多物种的生殖功能受损有关。本研究的目的是确定在产前发育期间暴露于DZ或乙炔雌二醇（EE）对大鼠后代卵巢的长期影响。妊娠第6-21天，妊娠大鼠分别给药5、60 mg DZ/kg体重/d或0.002 mg 17-α EE /kg体重/d。研究了雌性后代成年后卵巢相关终点。各治疗组卵巢表面上皮平均细胞高度均显著降低。卵泡发生的改变包括卵泡闭锁增加，第二和第三个卵泡数量减少和囊肿形成。还观察到发情期轻微延长的发生率升高。卵巢表面上皮的形态学改变与抗增殖作用一致，而卵巢卵泡发生受到不利影响。大剂量DZ的作用与17-α EE相似。
Daidzein (DZ), an isoflavone with the potential to interfere with estrogen signaling, is found in soy products, which have gained popularity due to purported beneficial effects on the cardiovascular and skeletal systems and potential antineoplastic properties. However, the ingestion of phytoestrogens has been associated with impaired reproductive function in many species. The aim of this study was to determine the long-term effects on the ovaries of rat offspring exposed to DZ or ethinyl estradiol (EE) during prenatal development. Gravid rats were administered either vehicle or 5 or 60 mg DZ/kg body weight/d or 0.002 mg 17-α EE /kg body weight/d on gestational days 6–21. Ovarian-related endpoints were investigated during adulthood in female offspring. The mean cell height of the ovarian surface epithelium was significantly reduced in all treated groups. Alterations in folliculogenesis included increased follicular atresia, a reduction in secondary and tertiary follicle numbers, and cyst formation. An elevated prevalence of a slightly prolonged estrus phase was also observed. The morphological changes to the ovarian surface epithelium are consistent with an antiproliferative effect, while ovarian folliculogenesis was adversely affected. The effects of the high dose DZ were similar to those observed with 17-α EE.
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