Stratification in health and survival after age 100: evidence from Danish centenarians.

Stratification in health and survival after age 100: evidence from Danish centenarians.
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DOI:
10.1186/s12877-021-02326-3
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发表时间:
2021-07-01
期刊:
影响因子:
4.1
通讯作者:
Christensen K
Christensen K
中科院分区:
医学2区
文献类型:
--
作者:
Alvarez JA;Medford A;Strozza C;Thinggaard M;Christensen K

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存在一个超级选择组的百岁老人,证明增加生存已被假设。然而,除了极端长寿之外,这个超级精选组是否具有类似的特征还不得而知。在这项研究中,我们分析了1895年、1905年和1910年出生的丹麦百岁老人的高质量健康和生存数据。我们使用潜在类别分析来识别未观察到的健康类别,并测试这些超级选择的生命是否具有相似的健康特征。我们发现,即使在100岁之后,健康状况也存在明显的梯度,并且这种梯度在不同出生队列的百岁老人中非常相似。根据健康水平,我们确定了三个集群的百岁老人-强大的,脆弱的和中间-并表明,这些群体有不同的生存前景。健壮的百岁老人最显著的特征是在不同的健康维度(身体、功能和认知)上表现出色。最后,我们表明,我们的健康类别分类是很好的预测百岁老人的生存前景。100岁以上的人在健康和功能方面有明显的分层,这些差异与100岁以上的生存有关。在线版本包含补充材料,可通过10.1186/s12877-021-02326-3获得。
The existence of a super-select group of centenarians that demonstrates increased survivorship has been hypothesized. However, it is unknown if this super-select group possesses similar characteristics apart from extreme longevity. In this study, we analyse high-quality health and survival data of Danish centenarians born in 1895, 1905 and 1910. We use Latent Class Analysis to identify unobserved health classes and to test whether these super-select lives share similar health characteristics. We find that, even after age 100, a clear and distinct gradient in health exists and that this gradient is remarkably similar across different birth cohorts of centenarians. Based on the level of health, we identify three clusters of centenarians - robust, frail and intermediate - and show that these groups have different survival prospects. The most distinctive characteristic of the robust centenarians is the outperformance in different health dimensions (physical, functional and cognitive). Finally, we show that our health class categorizations are good predictors of the survival prospects of centenarians. There is a clear stratification in health and functioning among those over 100 years of age and these differences are associated with survival beyond age 100. The online version contains supplementary material available at 10.1186/s12877-021-02326-3.
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