Current understanding of Pneumocystis immunology.
Current understanding of Pneumocystis immunology.
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DOI：
10.2217/fmb.09.116
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发表时间：
2010-01
影响因子：
3.1
通讯作者：
Shellito JE
中科院分区：
文献类型：
--
作者：
Kelly MN;Shellito JE
吉罗维西氏肺孢子虫是引起人类肺炎(PCP)的机会性真菌。与其他机会性病原体类似，肺孢子虫会在免疫功能受损的人身上致病，特别是那些感染艾滋病毒的人。PCP仍然是艾滋病患者最常见的机会性感染。随着HAART的出现，发病率大大下降。然而，发展中国家非艾滋病毒免疫缺陷人群的增加、对当前治疗的不依从、耐药菌株的出现以及艾滋病毒阳性病例的增加，使肺孢子虫成为持续令人感兴趣的病原体，并对公共卫生构成威胁。大量的研究兴趣涉及到治疗干预，以提高宿主日益减弱的免疫力，以预防或治疗PCP。本文主要介绍近5年来有关肺孢子虫宿主免疫应答的研究，包括先天免疫、细胞免疫和体液免疫，以及相关的免疫治疗方法。
Pneumocystis jirovecii is the opportunistic fungal organism that causes Pneumocystis pneumonia (PCP) in humans. Similar to other opportunistic pathogens, Pneumocystis causes disease in individuals who are immunocompromised, particularly those infected with HIV. PCP remains the most common opportunistic infection in patients with AIDS. Incidence has decreased greatly with the advent of HAART. However, an increase in the non-HIV immunocompromised population, noncompliance with current treatments, emergence of drug-resistant strains and rise in HIV+ cases in developing countries makes Pneumocystis a pathogen of continued interest and a public health threat. A great deal of research interest has addressed therapeutic interventions to boost waning immunity in the host to prevent or treat PCP. This article focuses on research conducted during the previous 5 years regarding the host immune response to Pneumocystis, including innate, cell-mediated and humoral immunity, and associated immunotherapies tested against PCP.
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