Prognostic factors of endometrial cancer in elderly patient group and their effects on survival.
Prognostic factors of endometrial cancer in elderly patient group and their effects on survival.
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DOI：
10.14744/nci.2020.47154
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发表时间：
2021
影响因子：
1
通讯作者：
Celik H
中科院分区：
文献类型：
--
作者：
Alemdaroglu S;Durdag GD;Baran SY;Simsek SY;Yetkinel S;Yaginc DA;Guler OC;Celik H
本研究的目的是通过检查诊断为子宫内膜癌（EC）的患者的组织病理学特征、手术治疗方案和治疗方式，探讨老年组的预后因素及其对生存的影响。回顾性评估了2012年至2019年在单个中心完成治疗和随访的397例EC患者的记录。患者分为年龄<70岁（301例，75.8%）和70岁以上（96例，24.2%）两组。在评估组织病理学特征和治疗方案后，采用Cox回归模型研究影响生存的独立危险因素。非子宫内膜样组织学（16.3% vs. 32.3%, p: 0.001）、高级别肿瘤（50.5% vs. 69.8%, p: 0.001）和>70年龄组的子宫内膜浸润（19.6% vs. 36.5%, p: 0.003）的发生率高于<70年龄组。影响bbb70年龄组总生存率的独立危险因素为非子宫内膜样组织学（HR: 5.9; 95% CI: 1.4 - 24.7）和淋巴结转移（HR: 6.4; 95% CI: 1.6-25.0）。在<70岁年龄组中，非子宫内膜样组织学（HR: 11.3; 95% CI: 4.0-32.0）被确定为影响5年生存率的唯一独立危险因素。EC具有非子宫内膜样组织学，尽管手术和辅助治疗相同，但在老年患者中观察到的发生率较高，是影响生存的主要因素。
The objective of the study was to investigate the prognostic factors of the elderly group and their effects on survival by examining the histopathological features, surgical treatment protocols, and treatment modalities of patients diagnosed with endometrial cancer (EC). The records of 397 EC patients who completed their treatment and follow-up at a single center between 2012 and 2019 were evaluated retrospectively. The patients were evaluated in two groups as <70 years old (n: 301; 75.8%) and >70 years old (n: 96; 24.2%). Following the evaluation of histopathological features and treatment protocols, independent risk factors influencing survival were investigated with the Cox regression model. The incidence of non-endometrioid histology (16.3% vs. 32.3%, p: 0.001), high-grade tumors (50.5% vs. 69.8%; p: 0.001), and >50 myometrial invasion (19.6% vs. 36.5%, p: 0.003) in the >70 age group was more frequent than that in the <70 age group. The independent risk factors on overall survival in the >70 age group were determined as non-endometrioid histology (HR: 5.9; 95% CI: 1.4– 24.7) and lymph node metastasis (HR: 6.4; 95% CI:1.6–25.0). In the <70 age group, non-endometrioid histology (HR: 11.3; 95% CI: 4.0–32.0) was identified as the only independent risk factor affecting 5-year survival. EC, with non-endometrioid histology, which is observed at a higher rate in elderly patients despite equal surgery and adjuvant therapy, is the primary factor that affects survival.
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DOI：
10.1097/igc.0000000000000605
发表时间：
2016-02-01
影响因子：
4.8
作者：
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DOI：
10.1055/s-0039-1688461
发表时间：
2019-05-01
期刊：
Revista Brasileira de Ginecologia e Obstetrícia
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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