The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans.
The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans.
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DOI：
10.1189/jlb.1210702
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发表时间：
2011-08
影响因子：
5.5
通讯作者：
Netea MG
中科院分区：
文献类型：
--
作者：
Cheng SC;van de Veerdonk FL;Lenardon M;Stoffels M;Plantinga T;Smeekens S;Rizzetto L;Mukaremera L;Preechasuth K;Cavalieri D;Kanneganti TD;van der Meer JW;Kullberg BJ;Joosten LA;Gow NA;Netea MG
侵袭的白念珠菌菌丝被巨噬细胞识别，激活caspase-1/IL-1β途径，并导致IL-17途径激活，从而控制白念珠菌感染。在粘膜中，区分侵袭性和侵袭性念珠菌的免疫途径，从而引起耐受或炎症，目前还知之甚少。白念珠菌菌丝诱导的Th17反应是激活粘膜抗真菌免疫的中心。白念珠菌菌丝激活炎症体，继而在巨噬细胞中释放活性的IL-1β是区分酵母菌和菌丝并诱导Th17反应的关键步骤。巨噬细胞的炎性小体激活是酵母和菌丝细胞壁结构差异的结果，部分是由Dectin-1/Syk途径介导的。这些结果将Dectin-1/炎症体途径定义为使宿主免疫系统能够启动保护性Th17反应并区分白色念珠菌的定植和组织侵袭的机制。
Invading C. albicans hyphae are recognized by macrophages, activate the caspase-1/IL-1β pathway, and lead to the activation of IL-17 pathway to control the C. albicans infection. In the mucosa, the immune pathways discriminating between colonizing and invasive Candida, thus inducing tolerance or inflammation, are poorly understood. Th17 responses induced by Candida albicans hyphae are central for the activation of mucosal antifungal immunity. An essential step for the discrimination between yeasts and hyphae and induction of Th17 responses is the activation of the inflammasome by C. albicans hyphae and the subsequent release of active IL-1β in macrophages. Inflammasome activation in macrophages results from differences in cell-wall architecture between yeasts and hyphae and is partly mediated by the dectin-1/Syk pathway. These results define the dectin-1/inflammasome pathway as the mechanism that enables the host immune system to mount a protective Th17 response and distinguish between colonization and tissue invasion by C. albicans.
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影响因子：
30.5
作者：
Acosta-Rodriguez, Eva V.;Napolitani, Giorgio;Sallusto, Federica
通讯作者：
Sallusto, Federica
DOI：
10.1086/523110
发表时间：
2007-11-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Gow NA;Netea MG;Munro CA;Ferwerda G;Bates S;Mora-Montes HM;Walker L;Jansen T;Jacobs L;Tsoni V;Brown GD;Odds FC;Van der Meer JW;Brown AJ;Kullberg BJ
通讯作者：
Kullberg BJ
影响因子：
16
作者：
Martinon, F;Burns, K;Tschopp, J
通讯作者：
Tschopp, J
影响因子：
4.4
作者：
Kankkunen, Paivi;Teirila, Laura;Matikainen, Sampsa
通讯作者：
Matikainen, Sampsa
影响因子：
64.5
作者：
Lo, HJ;Kohler, JR;Fink, GR
通讯作者：
Fink, GR