Autonomic nervous system and immune system interactions.
Autonomic nervous system and immune system interactions.
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DOI：
10.1002/cphy.c130051
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发表时间：
2014-07
影响因子：
5.8
通讯作者：
Ganta CK
中科院分区：
文献类型：
--
作者：
Kenney MJ;Ganta CK
本文对自主免疫整合生理过程的文献现状进行了评价，重点介绍了电生理学、药理学、分子生物学和中枢神经系统实验方法的研究。中枢自主神经网络通过多种通讯途径，包括神经和非神经途径，获知外周免疫状态。细胞因子和其他免疫因素影响支配不同靶点的交感神经和副交感神经中放电的活性和响应性。多个水平的神经轴参与了细胞因子诱导的传出副交感神经和交感神经流出的变化，导致了外周免疫反应的调节。局部交感免疫相互作用的功能取决于不同的信号机制所创造的微环境，包括交感神经系统神经递质和神经调节剂之间的整合；特定的肾上腺素能受体；以及免疫细胞、细胞因子和细菌的存在或不存在。胆碱能抗炎途径的功能机制可能涉及周围部位的胆碱能-肾上腺素能新的相互作用，包括自主神经节和淋巴靶点。免疫细胞表达肾上腺素能和尼古丁受体。交感神经末梢和副交感神经末梢释放的神经递质与位于免疫细胞表面的相应受体结合，启动免疫调节反应。自主神经系统的交感和副交感神经臂在协调神经免疫过程中都起着重要作用，尽管还需要更多的研究来了解动态和复杂的肾上腺素能-胆碱能相互作用。进一步了解连接交感神经、副交感神经和免疫系统的调节机制，对于了解慢性疾病的发展和自主神经系统功能的免疫相关变化之间的关系至关重要。
The present review assesses the current state of literature defining integrative autonomic-immune physiological processing, focusing on studies that have employed electrophysiological, pharmacological, molecular biological and central nervous system experimental approaches. Central autonomic neural networks are informed of peripheral immune status via numerous communicating pathways, including neural and non-neural. Cytokines and other immune factors affect the level of activity and responsivity of discharges in sympathetic and parasympathetic nerves innervating diverse targets. Multiple levels of the neuraxis contribute to cytokine-induced changes in efferent parasympathetic and sympathetic nerve outflows, leading to modulation of peripheral immune responses. The functionality of local sympathoimmune interactions depends on the microenvironment created by diverse signaling mechanisms involving integration between sympathetic nervous system neurotransmitters and neuromodulators; specific adrenergic receptors; and the presence or absence of immune cells, cytokines and bacteria. Functional mechanisms contributing to the cholinergic anti-inflammatory pathway likely involve novel cholinergic-adrenergic interactions at peripheral sites, including autonomic ganglion and lymphoid targets. Immune cells express adrenergic and nicotinic receptors. Neurotransmitters released by sympathetic and parasympathetic nerve endings bind to their respective receptors located on the surface of immune cells and initiate immune-modulatory responses. Both sympathetic and parasympathetic arms of the autonomic nervous system are instrumental in orchestrating neuroimmune processes, although additional studies are required to understand dynamic and complex adrenergic-cholinergic interactions. Further understanding of regulatory mechanisms linking the sympathetic nervous, parasympathetic nervous, and immune systems is critical for understanding relationships between chronic disease development and immune-associated changes in autonomic nervous system function.
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影响因子：
4.3
作者：
BARTIK, MM;BAUMAN, GP;ROSZMAN, TL
通讯作者：
ROSZMAN, TL
影响因子：
2.7
作者：
Borovikova, LV;Ivanova, S;Tracey, KJ
通讯作者：
Tracey, KJ
DOI：
10.1016/s0006-291x(05)80923-4
发表时间：
1990-12-31
影响因子：
3.1
作者：
AKIYOSHI, M;SHIMIZU, Y;SAITO, M
通讯作者：
SAITO, M
影响因子：
3.3
作者：
Bellinger, DL;Stevens, SY;Madden, KS
通讯作者：
Madden, KS
影响因子：
3.6
作者：
BOGNAR, IT;ALBRECHT, SA;FUDER, H
通讯作者：
FUDER, H