Association between decreased serum TBIL concentration and immediate memory impairment in schizophrenia patients
Association between decreased serum TBIL concentration and immediate memory impairment in schizophrenia patients
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精神分裂症患者血清 TBIL 浓度降低与即时记忆障碍之间的关系
DOI：
10.1038/s41598-018-38227-6
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发表时间：
2019-02
影响因子：
4.6
通讯作者：
Hui Li
中科院分区：
文献类型：
--
作者：
Yin Xiao Li;Jia Qiu Fang;Zhang Guang Ya;Zhang Jian Ping;Shirao Tomoaki;Jiang Cai Xia;Yin Xu Yuan;Liu Yan Song;Chen Peng;Gu Xiao Chu;Qian Zheng Kang;Yin Guang Zhong;Xia Hai Sen;Hui Li
认知障碍是精神分裂症（SCH）的核心特征。除了胆红素（BIL）的毒性作用外，它还具有与精神疾病的精神病理学和认知障碍相关的抗氧化特性。本研究的目的是探讨血清总胆红素（TBIL）浓度与SCH患者认知功能障碍的相关性。我们招募了34名SCH患者和119名健康对照（HC）在这种病例对照设计。认知功能采用神经心理状态评估可重复成套测验（RBANS）进行评估。采用免疫比浊法测定血清总胆红素浓度。调整年龄、性别和教育后，SCH患者的血清TBIL浓度显著低于HC患者。SCH患者血清TBIL浓度与RBANS即刻记忆评分呈正相关。进一步的逐步多元回归分析证实血清TBIL浓度与SCH患者的即时记忆评分呈正相关。我们的研究结果支持血清TBIL浓度的下降与SCH的即时记忆障碍和精神病理学有关。
Cognitive impairment is a core feature of schizophrenia (SCH). In addition to the toxic effect of Bilirubin (BIL), it has antioxidant properties that were associated with the psychopathology and cognitive impairment of psychiatric disorders. The aim of this study was to examine the correlation of serum total BIL (TBIL) concentration with cognitive impairment in SCH patients. We recruited 34 SCH patients and 119 healthy controls (HCs) in this case-control design. Cognition was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Serum TBIL concentration was measured using the immunoturbidimetric method. Serum TBIL concentration was significantly decreased in SCH patients compared to HCs after adjusting for age, gender, and education. Serum TBIL concentration in SCH patients was also positively correlated with the RBANS immediate memory score. Further stepwise multiple regression analysis confirmed the positive association between serum TBIL concentration and immediate memory score in SCH patients. Our findings supported that the decline in serum TBIL concentration was associated with the immediate memory impairment and psychopathology of SCH.
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DOI：
10.2218/resmedica.v21i1.510
发表时间：
2013-09
期刊：
--
影响因子：
--
作者：
T. Prentice
通讯作者：
T. Prentice
DOI：
--
发表时间：
1994
期刊：
--
影响因子：
--
作者：
T. Yamaguchif;Yasuo KomodaP;H. Nakajima
通讯作者：
T. Yamaguchif;Yasuo KomodaP;H. Nakajima
影响因子：
11.3
作者：
Rei Yasukawa;T. Miyaoka;H. Yasuda;M. Hayashida;T. Inagaki;Jun Horiguch
通讯作者：
Rei Yasukawa;T. Miyaoka;H. Yasuda;M. Hayashida;T. Inagaki;Jun Horiguch
影响因子：
11.3
作者：
J. Yao;R. Reddy;D. Kammen
通讯作者：
J. Yao;R. Reddy;D. Kammen
影响因子：
4.5
作者：
Addington, J;Brooks, BL;Addington, D
通讯作者：
Addington, D