Naphthoquine: A Potent Broad-Spectrum Anti-Coronavirus Drug In Vitro.
Naphthoquine: A Potent Broad-Spectrum Anti-Coronavirus Drug In Vitro.
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萘酚喹：一种有效的广谱体外抗冠状病毒药物
DOI：
10.3390/molecules27030712
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发表时间：
2022-01-21
期刊：
影响因子：
--
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Song Y;Deng Y;Wang H;Bei Z;Gu H;Zhao H;Wang H;Zhang D;Xu L;Wang B;Li Y;Wang H
COVID-19 已在世界范围内传播并造成严重的公共卫生和社会问题。尽管多种疫苗已被授权紧急使用，但仍需要新的有效抗病毒药物。一些重新利用的药物，包括氯喹、羟氯喹和瑞德西韦，在大流行后立即用于治疗 COVID-19。然而，这些药物的治疗效果尚未在临床研究中得到充分证明。在本文中，我们发现一种抗疟药物萘酚喹表现出良好的广谱抗冠状病毒活性。萘喹在体外抑制 HCoV-229E、HCoV-OC43 和 SARS-CoV-2 复制，IC50 分别 = 2.05 ± 1.44 μM、5.83 ± 0.74 μM 和 2.01 ± 0.38 μM。还进行了添加时间测定，以探索萘酚喹在 SARS-CoV-2 复制过程中的哪个阶段发挥作用。结果表明，萘酚喹可能会影响病毒的进入和进入后的复制。考虑到萘酚喹的安全性甚至优于氯喹，我们认为萘酚喹有潜力作为冠状病毒感染的广谱药物。
COVID-19 has spread around the world and caused serious public health and social problems. Although several vaccines have been authorized for emergency use, new effective antiviral drugs are still needed. Some repurposed drugs including Chloroquine, Hydroxychloroquine and Remdesivir were immediately used to treat COVID-19 after the pandemic. However, the therapeutic effects of these drugs have not been fully demonstrated in clinical studies. In this paper, we found an antimalarial drug, Naphthoquine, showed good broad-spectrum anti-coronavirus activity. Naphthoquineinhibited HCoV-229E, HCoV-OC43 and SARS-CoV-2 replication in vitro, with IC50 = 2.05 ± 1.44 μM, 5.83 ± 0.74 μM, and 2.01 ± 0.38 µM, respectively. Time-of-addition assay was also performed to explore at which stage Naphthoquine functions during SARS-CoV-2 replication. The results suggested that Naphthoquine may influence virus entry and post-entry replication. Considering the safety of Naphthoquine was even better than that of Chloroquine, we think Naphthoquine has the potential to be used as a broad-spectrum drug for coronavirus infection.
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