Sertoli-Leydig cell tumor with unique nail findings in a post-menopausal woman: a case report and literature review.
Sertoli-Leydig cell tumor with unique nail findings in a post-menopausal woman: a case report and literature review.
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DOI：
10.1186/s13048-014-0083-5
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发表时间：
2014-08-28
影响因子：
4
通讯作者：
Al-Hendy A
中科院分区：
文献类型：
--
作者：
Moghazy D;Sharan C;Nair M;Rackauskas C;Burnette R;Diamond M;Al-Hendy O;Al-Hendy A
支持-间质细胞瘤（SLCT）是一种罕见的性索肿瘤，通常发生在单侧，占所有卵巢肿瘤的< 0.5%。SLCT在绝经后妇女中不常见，平均诊断年龄为25岁。我们报告一位63岁的停经后妇女，以进行性多毛症及男性型秃发来表现。还观察到不寻常的指甲变化。患者的激素水平显示睾酮和雌二醇水平升高，左侧卵巢肿块3.5 cm。对患者进行了评估，没有发现贫血或缺铁。腹腔镜探查期间的术中冷冻切片评估显示SLCT，随后通过组织病理学和免疫组织化学（IHC）检查证实。从正常女性中收集甲床组织，并通过免疫组化法评估雄激素受体（AR）的存在。患者术后病程良好，所有睾酮相关表现在术后一年内均逆转。手术后，患者独特的指甲异常也逐渐消退。IHC评价还证实了雌性动物甲床组织中存在AR。SLCT，虽然罕见，应考虑绝经后妇女男性化和雄激素水平升高。这些患者的异常指甲体征可能是由于雄激素水平升高所致。
Sertoli-Leydig cell tumor (SLCT) is a rare sex-cord tumor that usually occurs unilaterally and accounts for < 0.5% of all ovarian tumors. SLCT is uncommon in post-menopausal women, with the average age of diagnosis being 25 years. We present a case of a 63-year-old post-menopausal woman presenting with progressive hirsutism, and male-pattern baldness. Unusual nail changes were also observed. Hormonal profile of the patient revealed increased testosterone and estradiol levels, and a 3.5 cm left ovarian mass. The patient was evaluated and was not found to be anemic or iron-deficient. Intraoperative frozen section assessment during laparoscopic exploration revealed SLCT, which was confirmed subsequently by histopathological and immunohistochemical (IHC) examination. Nail bed tissues were collected from normal females and evaluated by IHC for the presence of androgen receptors (AR). The patient had an excellent postoperative course and all her testosterone-related manifestations were reversed within one year of surgery. Following surgery, the patient’s unique nail abnormalities also resolved gradually. The IHC evaluation also confirmed the presence of AR in nail bed tissues of females. SLCT, albeit rare, should be considered in post-menopausal women presenting with virilization and elevated androgen levels. Unusual nail signs may develop in response to increased androgen levels in these patients.
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影响因子：
4.1
作者：
Downs JL;Wise PM
通讯作者：
Wise PM
影响因子：
3.7
作者：
Murakami R;Denda-Nagai K;Hashimoto S;Nagai S;Hattori M;Irimura T
通讯作者：
Irimura T
影响因子：
4.8
作者：
Berenbaum, Sheri A.;Bryk, Kristina Korman;Moffat, Scott
通讯作者：
Moffat, Scott
影响因子：
3.8
作者：
Nowak, Nicole T.;Moffat, Scott D.
通讯作者：
Moffat, Scott D.
DOI：
10.1016/0002-9378(84)90769-5
发表时间：
1984-01-01
影响因子：
9.8
作者：
GARZO, VG;DORRINGTON, JH
通讯作者：
DORRINGTON, JH