A framework for signaling throughout the life cycle of Babesia species.
A framework for signaling throughout the life cycle of Babesia species.
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DOI：
10.1111/mmi.14650
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发表时间：
2021-05
影响因子：
3.6
通讯作者：
Duraisingh, Manoj T.
中科院分区：
文献类型：
--
作者：
Elsworth, Brendan;Duraisingh, Manoj T.
巴贝虫是蜱传的细胞内寄生虫，感染哺乳动物宿主的红细胞，导致严重或致命的疾病。巴贝虫属感染广泛哺乳动物物种并在全球造成重大经济负担，主要是通过牛的疾病。几种巴氏杆菌属越来越多地被认为是人类的人畜共患病病原体。巴贝虫属具有复杂的生命周期，涉及蜱和哺乳动物宿主的多个阶段。寄生虫在这些阶段的每一个中的复制、外出和入侵期间利用复杂的信号传导途径。当它们在哺乳动物和蜱虫阶段之间切换时，它们还必须迅速对环境做出反应。本文将重点介绍巴氏巴贝菌的信号通路和环境刺激。利用在血液中和传输到蜱，重点是磷酸化和钙为基础的信号在出口和入侵的作用。扩大在体外和体内培养系统，基因组，转录组和转基因系统可用于一系列的巴氏杆菌属的可用性。应该鼓励对这些无处不在的寄生虫进行进一步的生物学和翻译研究。
Babesia species are tick-borne intracellular parasites that infect the red blood cells of their mammalian host, leading to severe or fatal disease. Babesia spp. infect a wide range of mammalian species and cause a significant economic burden globally, predominantly through disease in cattle. Several Babesia spp. are increasingly being recognized as zoonotic pathogens of humans. Babesia spp. have complex life cycles involving multiple stages in the tick and the mammalian host. The parasite utilizes complex signaling pathways during replication, egress and invasion in each of these stages. They must also rapidly respond to their environment when switching between the mammalian and tick stages. This review will focus on the signaling pathways and environmental stimuli that Babesia spp. utilize in the bloodstream and for transmission to the tick, with an emphasis on the role of phosphorylation- and calcium-based signaling during egress and invasion. The expanding availability of in vitro and in vivo culture systems, genomes, transcriptomes and transgenic systems available for a range of Babesia spp. should encourage further biological and translational studies of these ubiquitous parasites.
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