Sex differences in the associations of obstructive sleep apnoea with epidemiological factors.
Sex differences in the associations of obstructive sleep apnoea with epidemiological factors.
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DOI：
10.1183/13993003.02421-2017
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Redline S
中科院分区：
文献类型：
--
作者：
Huang T;Lin BM;Markt SC;Stampfer MJ;Laden F;Hu FB;Tworoger SS;Redline S
尽管众所周知，阻塞性睡眠呼吸暂停（OSA）的患病率以男性为主，但阻塞性睡眠呼吸暂停与一系列流行病学因素之间的性别差异仍不清楚。我们研究了2012-2013年来自护士健康研究（NHS）和NHS- ii的143326名女性（48-93岁）和22896名来自卫生专业人员随访研究（65-101岁）的自我报告的OSA患病率。通过人口统计学、人体测量学、生活方式和合并症等因素，采用多变量logistic回归估计OSA的性别特异性患病率优势比（pOR）和95%置信区间。自我报告的OSA总体患病率女性为6.4%，男性为13.8%。相互调整后，OSA与缺乏运动、高血压和日间嗜睡的相关性在女性中更强，而与腰围和呼吸暂停的相关性在男性中更强（p异质性<0.01）。在年龄（女性每5年增加的pOR为0.95,95% CI 0.94-0.96，男性为1.04,1.01-1.08，p异质性<0.0001）和婚姻状况（女性已婚与未婚的pOR为0.85,95% CI 0.81-0.89，男性为1.11,0.99-1.25，p异质性<0.0001）方面存在定性的性别差异。在与各种因素的关联中存在显著的性别差异，提示OSA的性别特异性机制。
Despite the well-known male predominance in the prevalence of obstructive sleep apnoea (OSA), sex differences in the associations between OSA and a comprehensive range of epidemiological factors remain less clear. We examined the prevalence of self-reported OSA in 143326 females (age 48–93 years) from the Nurses’ Health Study (NHS) and NHS-II and 22896 males from the Health Professionals Follow-up Study (age 65–101 years) in 2012–2013. Multivariable logistic regression was used to estimate the sex-specific prevalence odds ratios (pOR) and 95% confidence intervals of OSA by demographic, anthropometric, lifestyle and comorbidity factors. The overall prevalence of self-reported OSA was 6.4% in females and 13.8% in males. After mutual adjustment, the associations of OSA with physical inactivity, hypertension and daytime sleepiness were stronger in females, whereas the associations with waist circumference and witnessed apnoea were stronger in males (p-heterogeneity <0.01). There were qualitative sex differences in the associations with age (pOR per 5-year increment in females 0.95, 95% CI 0.94–0.96, and males 1.04, 1.01–1.08; p-heterogeneity <0.0001) and marital status (pOR for married versus other in females 0.85, 95% CI 0.81–0.89, and males 1.11, 0.99–1.25; p-heterogeneity <0.0001). Substantial sex differences exist in the associations with various factors, suggesting sex-specific mechanisms in OSA.
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影响因子：
24.3
作者：
Mokhlesi, Babak;Ham, Sandra A.;Gozal, David
通讯作者：
Gozal, David
影响因子：
5.6
作者：
Faux, MD;Larkin, EK;Redline, S
通讯作者：
Redline, S
影响因子：
4.3
作者：
Marshall, Nathaniel S.;Wong, Keith K. H.;Grunstein, Ronald R.
通讯作者：
Grunstein, Ronald R.
影响因子：
9.6
作者：
Chervin, RD
通讯作者：
Chervin, RD
DOI：
10.1183/09031936.00177411
发表时间：
2012-08
期刊：
The European respiratory journal
影响因子：
--
作者：
Morrell MJ;Finn L;McMillan A;Peppard PE
通讯作者：
Peppard PE