Cell Migration Guided by Cell-Cell Contacts in Innate Immunity.

Cell Migration Guided by Cell-Cell Contacts in Innate Immunity.
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先天免疫中细胞间接触引导的细胞迁移。

DOI:
10.1016/j.tcb.2020.11.002
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发表时间:
2021-03
影响因子:
19
通讯作者:
Huttenlocher, Anna
Huttenlocher, Anna
中科院分区:
生物学1区
文献类型:
--
作者:
Miskolci, Veronika;Klemm, Lucas C.;Huttenlocher, Anna

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白细胞向损伤或感染部位的定向迁移对于产生有效的免疫反应是必要的。有大量证据支持趋化物质在定向迁移中的关键作用,然而,关于细胞与细胞之间的接触如何影响天然免疫中白细胞的迁移行为,我们知道得很少。在这里,我们探索细胞-细胞接触如何影响先天免疫细胞的定向迁移,包括它们在吸引、排斥或停止细胞运动方面的作用。进一步研究细胞接触动力学作为指导线索,可能会对先天性免疫的调节产生新的见解。
The directed migration of leukocytes to sites of damage or infection is necessary for a productive immune response. There is substantial evidence supporting a key role for chemoattractants in directed migration, however less is known about how cell-cell contacts affect the migratory behavior of leukocytes in innate immunity. Here, we explore how cell-cell contacts can affect the directed migration of innate immune cells including their role in attracting, repelling or stopping cell motility. Further investigation of cell contact dynamics as guidance cues may yield new insights into the regulation of innate immunity.
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