Molecular epidemiology of feline immunodeficiency virus in the domestic cat (Felis catus).
Molecular epidemiology of feline immunodeficiency virus in the domestic cat (Felis catus).
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DOI：
10.1016/j.vetimm.2009.10.011
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发表时间：
2010-03-15
影响因子：
1.8
通讯作者：
Rodrigo AG
中科院分区：
文献类型：
--
作者：
Hayward JJ;Rodrigo AG
研究猫免疫缺陷病毒在家猫(Felis Catus)中的进化机制，可以很好地与其他慢病毒，如美洲狮(Puma Concolor)中的HIV和FIVPco进行比较。我们回顾了目前FIVFca的流行病学和进化研究结果。除了五个公认的FIVFca亚型外，最近的几项系统发育研究发现了形成独立分支的菌株，这表明新的亚型。在新西兰猫身上，这些未知亚型的菌株被发现参与了复杂的基因间重组模式，需要整个基因组序列来解决这些问题。重组事件的证据在env基因中的水平最高，env基因是参与宿主细胞受体识别的区域。已经报告了几例FIVFca，包括亚型间和亚型内的多重感染。未知亚型和相对较高的重组水平的发现表明，需要对当前的疫苗进行进一步测试。对FIVFca进化速度的有限研究表明，美洲狮的FIV值是FIV的两到三倍，这一结果表明病毒与各自宿主之间的共同适应程度不同。我们研究了FIVFca在野生家猫中的组织分布，发现了第一例FIV区隔，这一现象在HIV-1患者中得到了很好的记录。
Studying the evolutionary mechanisms of feline immunodeficiency virus in the domestic cat (Felis catus), FIVFca, provides a good comparison to other lentiviruses, such as HIV and FIVPco in the cougar (Puma concolor). We review the current epidemiological and evolutionary findings of FIVFca,. In addition to the five accepted FIVFca, subtypes, several recent phylogenetic studies have found strains that form separate clades, indicative of novel subtypes. In New Zealand cats, these strains of unknown subtype have been found to be involved in complex patterns of intergenic recombination, and whole genome sequences are required to resolve these. Evidence of recombination events has been documented with the highest levels in the env gene, the region involved in host cell receptor recognition. Several cases of FIVFca, multiple infection, both inter- and intra-subtype, have been reported. The findings of both unknown subtypes and relatively high levels of recombination suggest the need for further testing of the current vaccine. Limited studies on the evolutionary rate of FIVFca, document a value twice to three times that of FIV in the cougar, a result suggesting the different levels of co-adaptation between the viruses and their respective hosts. We studied the tissue distribution of FIVFca, in feral domestic cats, finding the first case of FIV compartmentalisation, a phenomenon well-documented in HIV-1 patients.
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影响因子：
3.3
作者：
Duarte, A;Tavares, L
通讯作者：
Tavares, L
影响因子：
4.8
作者：
Hayward, Jessica J.;Rodrigo, Allen G.
通讯作者：
Rodrigo, Allen G.
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作者：
Courchamp, F;Yoccoz, NG;Pontier, D
通讯作者：
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