Mature Retina Compensates Functionally for Partial Loss of Rod Photoreceptors.
Mature Retina Compensates Functionally for Partial Loss of Rod Photoreceptors.
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DOI：
10.1016/j.celrep.2020.107730
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发表时间：
2020-06-09
期刊：
影响因子：
8.8
通讯作者：
Dunn FA
中科院分区：
文献类型：
--
作者：
Care RA;Anastassov IA;Kastner DB;Kuo YM;Della Santina L;Dunn FA
初级神经元输入的丧失不可避免地会打击每一个神经回路。去传入电路可以传播、放大或减轻输入损耗，从而影响电路的输出。由于缺乏对电路元件的损失和访问的控制，去传入电路如何对输出的影响知之甚少。在这里，我们控制的时间和程度的杆感光器消融成熟小鼠视网膜和揭示补偿。在失去一半的视杆细胞后，视杆双极细胞通过保持电压输出来减轻损失。这种缓解允许部分恢复神经节细胞反应。我们的结论是，杆死亡补偿电路中，因为神经节细胞的反应，刺激的一半杆在一个未受干扰的电路是弱于响应后死亡的一半杆。这种补偿的主要机制包括抑制的稳态调节以平衡兴奋的丧失。Care等人消融了成熟小鼠视网膜中的一半视杆细胞，发现初级神经元的损失在功能上通过次级神经元的平衡抑制和兴奋得到补偿。视锥细胞介导的，但不是视杆细胞介导的，输出神经元尖峰的变化被半刺激重演，表明独立的调节途径。
Loss of primary neuronal inputs inevitably strikes every neural circuit. The deafferented circuit could propagate, amplify, or mitigate input loss, thus affecting the circuit’s output. How the deafferented circuit contributes to the effect on the output is poorly understood because of lack of control over loss of and access to circuit elements. Here, we control the timing and degree of rod photoreceptor ablation in mature mouse retina and uncover compensation. Following loss of half of the rods, rod bipolar cells mitigate the loss by preserving voltage output. Such mitigation allows partial recovery of ganglion cell responses. We conclude that rod death is compensated for in the circuit because ganglion cell responses to stimulation of half of the rods in an unperturbed circuit are weaker than responses after death of half of the rods. The dominant mechanism of such compensation includes homeostatic regulation of inhibition to balance the loss of excitation. Care et al. ablate half of the rods in mature mouse retina and find that primary neuron loss is functionally compensated for by balanced inhibition and excitation at the secondary neuron. Changes in cone-mediated, but not rod-mediated, output neuron spikes are recapitulated by half stimulation, demonstrating independent regulation of pathways.
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影响因子：
5.3
作者：
Kim, KJ;Rieke, F
通讯作者：
Rieke, F
影响因子：
5.5
作者：
BARLOW, HB
通讯作者：
BARLOW, HB
影响因子：
48
作者：
Buch, T;Heppner, FL;Waisman, A
通讯作者：
Waisman, A
影响因子：
4.1
作者：
PERLMAN, I
通讯作者：
PERLMAN, I
影响因子：
2.5
作者：
SHIMAZU, H;PRECHT, W
通讯作者：
PRECHT, W