Conditional specification of endomesoderm.
Conditional specification of endomesoderm.
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DOI：
10.1016/j.cdev.2021.203716
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发表时间：
2021-09
影响因子：
3.9
通讯作者：
Warner JF
中科院分区：
文献类型：
--
作者：
McClay DR;Croce JC;Warner JF
在动物发育的早期，许多细胞是有条件地指定的，因为观察到这些细胞可以导向不同的命运。内胚层之所以被称为内胚层，是因为早期规格产生的细胞通常被观察到同时表达早期内胚层和中胚层转录因子。对这些细胞的实验表明，它们的后代可以完全定向到内胚层或中胚层，而正常情况下，它们建立两个胚层。本文综述了启动条件性内胚层状态的机制，它的亚稳性，以及将这种状态分解成确定的内胚层和中胚层的机制。
Early in animal development many cells are conditionally specified based on observations that those cells can be directed toward alternate fates. The endomesoderm is so named because early specification produces cells that often have been observed to simultaneously express both early endoderm and mesoderm transcription factors. Experiments with these cells demonstrate that their progeny can directed entirely toward endoderm or mesoderm, whereas normally they establish both germ layers. This review examines the mechanisms that initiate the conditional endomesoderm state, its metastability, and the mechanisms that resolve that state into definitive endoderm and mesoderm.
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