BOLD signal and functional connectivity associated with loving kindness meditation.
BOLD signal and functional connectivity associated with loving kindness meditation.
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DOI：
10.1002/brb3.219
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发表时间：
2014-05
影响因子：
3.1
通讯作者：
Brewer, Judson A.
中科院分区：
文献类型：
--
作者：
Garrison, Kathleen A.;Scheinost, Dustin;Constable, R. Todd;Brewer, Judson A.
慈心是一种涉及直接祝福的冥想形式，通常通过默默重复“愿众生幸福”等短语来支持，以培养无私的爱的感觉。在这里，我们使用功能性磁共振成像来评估经验丰富的冥想者和新手的慈心冥想的神经基础。我们首先评估了慈心冥想期间血氧水平依赖性（BOLD）信号的群体差异。接下来，我们使用了一种相对新颖的方法，即功能连接的内在连接分布，来识别组之间内在连接不同的区域，然后使用数据驱动的方法进行基于种子的连接分析，以确定组之间哪些连接不同。我们的研究结果表明，涉及自我相关处理和走神、情绪处理、内心言语和记忆的大脑区域存在群体差异。与新手相比，冥想者在慈爱期间表现出 BOLD 信号和内在连接性总体减少，特别是在后扣带皮层/楔前叶 (PCC/PCu) 中，这一发现与我们之前的工作和其他最近的冥想神经影像学研究一致。此外，冥想者在慈爱过程中 PCC/PCu 和左额下回之间表现出更大的功能连接，而新手在慈爱过程中 PCC/PCu 和默认模式网络的其他皮质中线区域、双侧岛叶后叶和双侧海马旁回/海马之间表现出更大的功能连接。这些新颖的发现表明，与新手相比，慈心冥想涉及冥想者以当下为中心、无私的关注。
Loving kindness is a form of meditation involving directed well-wishing, typically supported by the silent repetition of phrases such as “may all beings be happy,” to foster a feeling of selfless love. Here we used functional magnetic resonance imaging to assess the neural substrate of loving kindness meditation in experienced meditators and novices. We first assessed group differences in blood oxygen level-dependent (BOLD) signal during loving kindness meditation. We next used a relatively novel approach, the intrinsic connectivity distribution of functional connectivity, to identify regions that differ in intrinsic connectivity between groups, and then used a data-driven approach to seed-based connectivity analysis to identify which connections differ between groups. Our findings suggest group differences in brain regions involved in self-related processing and mind wandering, emotional processing, inner speech, and memory. Meditators showed overall reduced BOLD signal and intrinsic connectivity during loving kindness as compared to novices, more specifically in the posterior cingulate cortex/precuneus (PCC/PCu), a finding that is consistent with our prior work and other recent neuroimaging studies of meditation. Furthermore, meditators showed greater functional connectivity during loving kindness between the PCC/PCu and the left inferior frontal gyrus, whereas novices showed greater functional connectivity during loving kindness between the PCC/PCu and other cortical midline regions of the default mode network, the bilateral posterior insula lobe, and the bilateral parahippocampus/hippocampus. These novel findings suggest that loving kindness meditation involves a present-centered, selfless focus for meditators as compared to novices.
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影响因子：
12.8
作者：
Hofmann, Stefan G.;Grossman, Paul;Hinton, Devon E.
通讯作者：
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