On-Chip Cyclic Voltammetry Measurements Using a Compact 1024-Electrode CMOS IC.
On-Chip Cyclic Voltammetry Measurements Using a Compact 1024-Electrode CMOS IC.
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DOI：
10.1021/acs.analchem.1c01132
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发表时间：
2021-06-08
影响因子：
7.4
通讯作者：
Lindau M
中科院分区：
文献类型：
--
作者：
Huang M;Dorta-Quiñones CI;Minch BA;Lindau M
互补金属氧化物半导体（CMOS）微电极阵列将放大器阵列与片上电极集成，为具有高空间和时间分辨率的电化学传感提供高通量平台。这样的设备已被开发用于高度并行的恒定电压安培检测发射器释放从多个细胞与单囊泡分辨率。循环伏安法（CV）是一种应用电压波形的电化学方法，它提供了有关电极特性和分析物性质的额外信息。介绍了一种采用0.5 μ mCMOS工艺制作的16通道、64电极/通道的恒压CMOS集成电路。每个探测器仅由11个晶体管和一个单位尺寸为0.0015 mm 2的积分电容器组成。使用Pt作为具有移位电极设计的工作电极材料后制造该装置，这使得可以重新定义工作电极的尺寸和位置。采用多巴胺注射试验和1 V/s扫描速率下铁氰化钾的CV测量验证了包含细胞大小（8 μm半径）微电极的系统。循环伏安图与理论预测非常吻合。该技术能够对CMOS微电极阵列在量子发射器释放的低噪声电流测量以及其他生物传感应用中的电极性能进行严格表征。
Complementary metal–oxide–semiconductor (CMOS) microelectrode arrays integrate amplifier arrays with on-chip electrodes, offering high-throughput platforms for electrochemical sensing with high spatial and temporal resolution. Such devices have been developed for highly parallel constant voltage amperometric detection of transmitter release from multiple cells with single-vesicle resolution. Cyclic voltammetry (CV) is an electrochemical method that applies voltage waveforms, which provides additional information about electrode properties and about the nature of analytes. A 16-channel, 64-electrode-per-channel CMOS integrated circuit (IC) fabricated in a 0.5 μm CMOS process for CV is demonstrated. Each detector consists of only 11 transistors and an integration capacitor with a unit dimension of 0.0015 mm2. The device was postfabricated using Pt as the working electrode material with a shifted electrode design, which makes it possible to redefine the size and the location of working electrodes. The system incorporating cell-sized (8 μm radius) microelectrodes was validated with dopamine injection tests and CV measurements of potassium ferricyanide at a 1 V/s scanning rate. The cyclic voltammograms were in excellent agreement with theoretical predictions. The technology enables rigorous characterization of electrode performance for the application of CMOS microelectrode arrays in low-noise amperometric measurements of quantal transmitter release as well as other biosensing applications.
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影响因子：
7.4
作者：
Picollo, Federico;Battiato, Alfio;Carabelli, Valentina
通讯作者：
Carabelli, Valentina
影响因子：
4.6
作者：
Picollo F;Battiato A;Bernardi E;Plaitano M;Franchino C;Gosso S;Pasquarelli A;Carbone E;Olivero P;Carabelli V
通讯作者：
Carabelli V
影响因子：
7.4
作者：
Berberian, Khajak;Kisler, Kassandra;Lindau, Manfred
通讯作者：
Lindau, Manfred
影响因子：
2.8
作者：
Gao Y;Chen X;Gupta S;Gillis KD;Gangopadhyay S
通讯作者：
Gangopadhyay S
DOI：
10.1109/tcsi.2006.888777
发表时间：
2007-04-01
影响因子：
5.1
作者：
Ayers, Sunitha;Gillis, Kevin D.;Minch, Bradley A.
通讯作者：
Minch, Bradley A.