Epigenetic Determinants of Racial Disparity in Breast Cancer: Looking beyond Genetic Alterations.
Epigenetic Determinants of Racial Disparity in Breast Cancer: Looking beyond Genetic Alterations.
复制标题
乳腺癌中种族差异的表观遗传决定因素：超越遗传改变。
DOI：
10.3390/cancers14081903
复制
发表时间：
2022-04-09
期刊：
影响因子：
5.2
通讯作者：
Aneja, Ritu
中科院分区：
文献类型：
--
作者：
Joshi, Shriya;Garlapati, Chakravarthy;Aneja, Ritu
非裔美国人（AA）和欧裔美国人（EA）妇女之间乳腺癌发病率和死亡率存在很大差异。然而，人们对这些差异的基础知之甚少。在本文中，我们描述了通过表观遗传修饰介导的基因-环境相互作用可能在BC发病率和结果的种族差异中发挥重要作用。我们的计算机分析和深入的文献调查表明，AA和EA乳腺癌妇女之间的表观遗传模式存在显着差异。在此，我们描述了导致这些表观遗传变化的环境因素，这可能是乳腺癌患者不同种族负担的基础。我们认为，AA妇女具有较高的基础表观遗传学变化，可能有较高的易感性，癌症的发病，和侵略性的疾病过程。乳腺组织表观遗传特征中预先存在的种族差异提高了检查这些特征以进行早期诊断的可能性。乳腺癌（BC）是女性最常见的癌症。尽管在BC筛查，预防和治疗方面取得了进展，但BC的发病率和死亡率在非洲裔美国人（AA）妇女中仍然很高。与欧洲美国（EA）妇女相比，AA妇女往往被诊断为更先进和侵略性的肿瘤，并表现出更差的生存结果。大多数调查BC种族差异决定因素的研究都集中在与非洲血统相关的遗传因素上。然而，在一个人的生命历程中，各种环境和社会压力也可以塑造BC的种族分层。这些社会和环境暴露导致表观遗传机制介导的基因表达的长期变化。表观遗传学通常被描述为社会模式压力和基因表达的交叉点。表观遗传变化的持久性使其适合于研究个体生命过程中不同环境暴露对基因表达的影响。不同的社会和环境暴露在BC种族差异中的作用表明，AA和EA女性中与特定BC亚型相关的表观遗传特征或签名不同。EA和AA妇女的这些表观遗传特征可用作早期BC诊断和疾病预后的生物标志物，并可能对BC的靶向治疗的发展有价值。这篇综述文章讨论了目前的知识状态关于AA和EA妇女与BC之间的表观遗传差异。我们还讨论了社会环境因素的作用，包括社会心理压力，环境毒物，饮食因素，在划定不同的表观遗传配置文件AA和EA患者BC。
A substantial disparity in breast cancer incidence and mortality exists between African American (AA) and European American (EA) women. However, the basis for these disparities is poorly understood. In this article, we describe that gene–environment interactions mediated through epigenetic modifications may play a significant role in racial disparities in BC incidence and outcomes. Our in silico analyses and an in-depth literature survey suggest that there exists a significant difference in epigenetic patterns between AA and EA women with breast cancer. Herein, we describe the environmental factors that contribute to these epigenetic changes, which may underlie the disparate racial burden in patients with breast cancer. We suggest that AA women with higher basal epigenetic changes, may have higher pre-disposition to cancer onset, and an aggressive disease course. Pre-existing racial differences in epigenetic profiles of breast tissues raises the possibility of examining these profiles for early diagnosis. Breast cancer (BC) is the most commonly diagnosed cancer in women. Despite advancements in BC screening, prevention, and treatment, BC incidence and mortality remain high among African American (AA) women. Compared with European American (EA) women, AA women tend to be diagnosed with more advanced and aggressive tumors and exhibit worse survival outcomes. Most studies investigating the determinants of racial disparities in BC have focused on genetic factors associated with African ancestry. However, various environmental and social stressors over an individual’s life course can also shape racial stratification in BC. These social and environmental exposures result in long-term changes in gene expression mediated by epigenetic mechanisms. Epigenetics is often portrayed as an intersection of socially patterned stress and genetic expression. The enduring nature of epigenetic changes makes them suitable for studying the effects of different environmental exposures over an individual’s life course on gene expression. The role of differential social and environmental exposures in racial disparities in BC suggests varied epigenetic profiles or signatures associated with specific BC subtypes in AA and EA women. These epigenetic profiles in EA and AA women could be used as biomarkers for early BC diagnosis and disease prognosis and may prove valuable for the development of targeted therapies for BC. This review article discusses the current state of knowledge regarding epigenetic differences between AA and EA women with BC. We also discuss the role of socio-environmental factors, including psychosocial stress, environmental toxicants, and dietary factors, in delineating the different epigenetic profiles in AA and EA patients with BC.
登录
查看更多内容
DOI：
10.1016/j.bbcan.2017.01.001
发表时间：
2017-08
期刊：
Biochimica et biophysica acta. Reviews on cancer
影响因子：
--
作者：
Ahmad A;Azim S;Zubair H;Khan MA;Singh S;Carter JE;Rocconi RP;Singh AP
通讯作者：
Singh AP
DOI：
10.1186/bcr3646
发表时间：
2014-04-19
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Bérubé S;Lemieux J;Moore L;Maunsell E;Brisson J
通讯作者：
Brisson J
影响因子：
3.8
作者：
Conway K;Edmiston SN;Parrish E;Bryant C;Tse CK;Swift-Scanlan T;McCullough LE;Kuan PF
通讯作者：
Kuan PF
影响因子：
6.3
作者：
Chakraborty, Jayajit;Zandbergen, Paul A.
通讯作者：
Zandbergen, Paul A.
影响因子：
3.7
作者：
Azare, Janeen;Doane, Ashley;Bromberg, Jacqueline
通讯作者：
Bromberg, Jacqueline