The biological effects of individual-level PM2.5 exposure on systemic immunity and inflammatory response in traffic policemen
The biological effects of individual-level PM2.5 exposure on systemic immunity and inflammatory response in traffic policemen
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个体水平PM2.5暴露对交警全身免疫和炎症反应的生物学影响
DOI：
10.1136/oemed-2012-100864
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发表时间：
2013-01
影响因子：
4.9
通讯作者：
Song, Weimin
中科院分区：
文献类型：
--
作者：
Xin, Feng;Jiang, Rongfang;Kan, Haidong;Song, Weimin
研究背景大气细颗粒物（PM2.5）暴露与肺功能下降、冠心病患病率和心肌梗死发病率相关。本研究旨在观察大气PM2.5对心血管系统的影响，并探讨其潜在的炎症和免疫机制。方法以上海市110名25-55岁的交通警察为研究对象。 分别在冬季和夏季进行了两次连续24小时的个体水平PM2.5测量。检测外周血炎症标志物（超敏C反应蛋白，hs-CRP）、免疫指标（伊加、IgG、IgM和IgE）和淋巴细胞（CD 4 T细胞、CD 8 T细胞、CD 4/CD 8 T细胞）。采用多元线性回归分析个体水平PM2.5与炎症标志物和免疫指标之间的关系。结果24 h个人PM2.5平均浓度冬季为116.98 μg/m3，夏季为86.48 μg/m3; 在主要分析中，PM2.5暴露与参与者的hs-CRP增加1.1%，IgG增加6.7%，IgM增加11.2%，IgE增加3.3%，伊加减少4.7%，CD 8减少0.7%，而我们发现CD 4 T细胞和CD 4/CD 8 T细胞无统计学相关性。在调整模型中，结果表明，PM2. 5的增加与冬季和夏季的炎症标志物和免疫标志物的变化相关。结论交通警察是PM2.5暴露的高危人群，可能会产生炎症反应或免疫损伤。这些发现为PM2.5与炎症和免疫反应之间的联系机制提供了新的见解。
Background Ambient fine-particle particulate matter (PM2.5) exposure is associated with the decline in pulmonary function, prevalence of coronary heart disease and incidence of myocardial infarction. The study is to observe the effects of ambient PM2.5 on the cardiovascular system and to explore the potential inflammatory and immune mechanisms. Methods The subjects included 110 traffic policemen in Shanghai, China, who were aged 25–55 years. Two-times continuous 24 h individual-level PM2.5 measurements were performed in winter and summer, respectively. The inflammatory marker (high-sensitivity C-reactive protein, hs-CRP), immune parameters (IgA, IgG, IgM and IgE) and lymphocyte profiles (CD4 T cells, CD8 T cells, CD4/CD8 T cells) were measured in blood. The associations between individual-level PM2.5 and inflammatory marker and immune parameters were analysed by multiple linear regression. Results The average concentration of 24 h personal PM2.5 for participants was 116.98 μg/m3 and 86.48 μg/m3 in winter and summer, respectively. In the main analysis, PM2.5 exposure is associated with the increases in hs-CRP of 1.1%, IgG of 6.7%, IgM of 11.2% and IgE of 3.3% in participants, and decreases in IgA of 4.7% and CD8 of 0.7%, whereas we found no statistical association in CD4 T cells and CD4/CD8 T cells. In the adjusted model, the results showed that the increase of PM2.5 was associated with the changes of inflammatory markers and immune markers both in winter and summer. Conclusions Traffic policeman have been a high-risk group suffering inflammatory response or immune injury because of the high exposure to PM2.5. These findings provided new insight into the mechanisms linking ambient PM2.5 and inflammatory and immune response.
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影响因子：
10.4
作者：
通讯作者：
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影响因子：
10.4
作者：
Rückerl R;Greven S;Ljungman P;Aalto P;Antoniades C;Bellander T;Berglind N;Chrysohoou C;Forastiere F;Jacquemin B;von Klot S;Koenig W;Küchenhoff H;Lanki T;Pekkanen J;Perucci CA;Schneider A;Sunyer J;Peters A;AIRGENE Study Group
通讯作者：
AIRGENE Study Group
影响因子：
3.5
作者：
Jinzhuo Zhao;Yuquan Xie;Xiaolin Qian;R. Jiang;Weimin Song
通讯作者：
Jinzhuo Zhao;Yuquan Xie;Xiaolin Qian;R. Jiang;Weimin Song
DOI：
10.1080/00039890109604484
发表时间：
2001-09-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
Karita, K;Yano, E;Tamura, K
通讯作者：
Tamura, K
DOI：
10.3760/cma.j.issn.1001-9391.2007.09.007
发表时间：
2007-09
影响因子：
--
作者：
Xu Yang;Chang-li Yue;Qin Wang;Ning-hua Huang;Dongqun Xu;Hong-Gang Liu
通讯作者：
Xu Yang;Chang-li Yue;Qin Wang;Ning-hua Huang;Dongqun Xu;Hong-Gang Liu