Molecular mechanisms controlling E-cadherin expression in breast cancer.
Molecular mechanisms controlling E-cadherin expression in breast cancer.
复制标题
控制乳腺癌中e-钙粘蛋白表达的分子机制。
DOI：
10.1016/j.bbrc.2009.04.051
复制
发表时间：
2009-06-19
影响因子：
3.1
通讯作者：
Alahari, Suresh K.
中科院分区：
文献类型：
--
作者：
Baranwal, Somesh;Alahari, Suresh K.
细胞-细胞粘附的破坏是癌症进展中的初始事件，细胞-细胞粘附对于维持上皮可塑性是必不可少的，并且由一类称为钙粘蛋白的蛋白质介导。钙粘蛋白是钙离子依赖性跨膜蛋白，通过其他细胞质蛋白与肌动蛋白结合。在癌症进展期间细胞-细胞粘附的破坏是癌症起始和转移期间的重要事件。E-钙粘蛋白属于钙依赖性细胞粘附分子家族，是乳腺癌中研究最广泛的肿瘤抑制因子之一。多种信号分子和转录因子调节E-cadherin的表达。据报道，E-钙粘蛋白的缺失在几种癌症中诱导上皮-间充质转化。这篇综述强调了最近的进展，确定机制，调节E-钙粘蛋白在乳腺癌的表达。
Disruption of cell-cell adhesion, which is essential for the maintenance of epithelial plasticity and is mediated by a class of proteins called cadherins, is an initial event in the progression of cancer. Cadherins are Ca2+-dependent transmembrane proteins that are associated with actin via other cytoplasmic proteins. Disruption of cell-cell adhesion during cancer progression is an important event during cancer initiation and metastasis. E-cadherin, one of the most widely studied tumor suppressors in breast cancer, belongs to a family of calcium-dependent cell adhesion molecules. Various signaling molecules and transcription factors regulate the expression of E-cadherin. Loss of E-cadherin has been reported to induce epithelial-mesenchymal transition in several cancers. This review highlights recent advances in defining the mechanisms that regulate E-cadherin expression in breast cancer.
登录
查看更多内容
N-钙粘着蛋白在乳腺癌细胞中的外源表达会诱导细胞迁移，侵袭和转移。
影响因子：
7.8
作者：
Hazan, R B;Phillips, G R;Qiao, R F;Norton, L;Aaronson, S A
通讯作者：
Aaronson, S A
影响因子：
3.9
作者：
Nelson, W. James
通讯作者：
Nelson, W. James
影响因子：
4.5
作者：
Christoffersen, Nanna Ronbjerg;Silahtaroglu, Asli;Lund, Anders H.
通讯作者：
Lund, Anders H.
影响因子：
11.2
作者：
Hurteau, Gregory J.;Carlson, J. Andrew;Brock, Graham J.
通讯作者：
Brock, Graham J.
影响因子：
11.4
作者：
Berx, G;CletonJansen, AM;vanRoy, F
通讯作者：
vanRoy, F