Keeping an eye on SOXC proteins.

Keeping an eye on SOXC proteins.
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DOI:
10.1002/dvdy.24235
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发表时间:
2015-03
期刊:
Developmental dynamics : an official publication of the American Association of Anatomists
影响因子:
--
通讯作者:
Morris AC
Morris AC
中科院分区:
其他
文献类型:
--
作者:
Pillai-Kastoori L;Wen W;Morris AC

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成熟、功能眼的形成需要一系列复杂的细胞增殖、迁移、不同生发层之间的诱导和细胞分化。这些过程受到细胞外信号的调控,如Wnt/BMP/Hh/Fgf信号通路,以及指定细胞命运的细胞内在转录因子。在这篇综述文章中,我们概述了胚胎眼形态发生的各个阶段,每个阶段所需的外在和内在因素,以及与眼睛发育缺陷相关的儿童眼部疾病。此外,我们还关注了最近关于SOXC蛋白在调节脊椎动物眼部发育中的作用以及SOXC突变在人类眼部畸形中的作用。
The formation of a mature, functional eye requires a complex series of cell proliferation, migration, induction among different germinal layers, and cell differentiation. These processes are regulated by extracellular cues such as the Wnt/BMP/Hh/Fgf signaling pathways, as well as cell intrinsic transcription factors that specify cell fate. In this review article we provide an overview of stages of embryonic eye morphogenesis, extrinsic and intrinsic factors that are required for each stage, and pediatric ocular diseases that are associated with defective eye development. In addition, we focus on recent findings about the roles of the SOXC proteins in regulating vertebrate ocular development and implicating SOXC mutations in human ocular malformations.
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