Keeping an eye on SOXC proteins.
Keeping an eye on SOXC proteins.
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DOI:
10.1002/dvdy.24235
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发表时间:
2015-03
期刊:
影响因子:
--
通讯作者:
Morris AC
中科院分区:
文献类型:
--
作者:
Pillai-Kastoori L;Wen W;Morris AC
The formation of a mature, functional eye requires a complex series of cell proliferation, migration, induction among different germinal layers, and cell differentiation. These processes are regulated by extracellular cues such as the Wnt/BMP/Hh/Fgf signaling pathways, as well as cell intrinsic transcription factors that specify cell fate. In this review article we provide an overview of stages of embryonic eye morphogenesis, extrinsic and intrinsic factors that are required for each stage, and pediatric ocular diseases that are associated with defective eye development. In addition, we focus on recent findings about the roles of the SOXC proteins in regulating vertebrate ocular development and implicating SOXC mutations in human ocular malformations.
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