sox4 and sox11 function during Xenopus laevis eye development.
sox4 and sox11 function during Xenopus laevis eye development.
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DOI：
10.1371/journal.pone.0069372
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Kühl SJ
中科院分区：
文献类型：
--
作者：
Cizelsky W;Hempel A;Metzig M;Tao S;Hollemann T;Kühl M;Kühl SJ
SoxC基因参与许多发育过程，如心脏、淋巴和骨骼发育。SoxC基因家族由Sox4、Sox11和Sox12代表。Sox4或Sox11功能的丧失在小鼠胚胎发育过程中是致命的。在这里，我们证明，sox4和sox11强烈表达在非洲爪蟾的眼睛，心脏以及大脑的发展。在前部神经组织中，吗啉代寡核苷酸介导的敲除方法揭示了Sox4或Sox11功能的干扰会影响眼睛发育。详细的分析表明对眼睛大小和视网膜分层有强烈的影响。神经诱导Sox4或Sox11 MO注射后不受影响，早期眼区分化和细胞增殖仅受到轻度影响。然而，这两种基因的缺失独立地导致眼睛中细胞凋亡的显著增加。总之，Sox4和Sox11是爪蟾视觉系统发育所必需的。
SoxC genes are involved in many developmental processes such as cardiac, lymphoid, and bone development. The SoxC gene family is represented by Sox4, Sox11, and Sox12. Loss of either Sox4 or Sox11 function is lethal during mouse embryogenesis. Here, we demonstrate that sox4 and sox11 are strongly expressed in the developing eye, heart as well as brain in Xenopus laevis. Morpholino oligonucleotide mediated knock-down approaches in anterior neural tissue revealed that interference with either Sox4 or Sox11 function affects eye development. A detailed analysis demonstrated strong effects on eye size and retinal lamination. Neural induction was unaffected upon Sox4 or Sox11 MO injection and early eye field differentiation and cell proliferation were only mildly affected. Depletion of both genes, however, led independently to a significant increase in cell apoptosis in the eye. In summary, Sox4 and Sox11 are required for Xenopus visual system development.
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10.1016/j.biocel.2009.07.018
发表时间：
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影响因子：
4
作者：
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通讯作者：
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影响因子：
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DOI：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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影响因子：
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