Excipient exposure in very low birth weight preterm neonates.
Excipient exposure in very low birth weight preterm neonates.
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DOI：
10.1038/jp.2017.165
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Mooney SM
中科院分区：
文献类型：
--
作者：
Akinmboni TO;Davis NL;Falck AJ;Bearer CF;Mooney SM
在新生儿重症监护室使用的药物中存在着苯甲醇、丙二醇和乙醇等赋形剂。暴露于高水平会对新生儿产生不良影响。目的是量化极低出生体重（VLBW）新生儿的辅料暴露，并确定与较高暴露相关的危险因素。一年内入院的VLBW婴儿的回顾性记录回顾。计算了辅料暴露量，并通过多变量回归分析确定了增加暴露的危险因素。98%的受试者至少接触过一种辅料。5-9%的人接受的剂量高于成人的建议剂量。坏死性小肠结肠炎、癫痫发作、支气管肺发育不良和较长的住院时间预示着较高的辅料暴露。所检查的辅料是通常用于极低体重新生儿的药物，累积剂量可能超过成人的建议暴露量。虽然安全性还没有确定，但对于这一人群，明智地使用含有这些赋形剂的药物是必要的。
The excipients benzyl alcohol, propylene glycol and ethanol are present in medications used in the NICU. Exposure to high levels can have adverse effects in a neonatal population. The objective was to quantify excipient exposure in Very Low Birth Weight (VLBW) neonates and identify risk factors associated with greater exposure. A retrospective record review of VLBW infants admitted over one year. Excipient exposures were calculated and multivariable regression analyses identified risk factors for increasing exposure. 98% of subjects were exposed to at least one excipient. 5–9% received doses higher than recommended for adults. Necrotizing enterocolitis, seizure, bronchopulmonary dysplasia, and longer stay predicted higher excipient exposure. The excipients examined are in medications commonly prescribed for VLBW neonates, and cumulative doses may exceed recommended exposures for adults. Although safety profiles have not been established, judicious use of medication containing these excipients is warranted for this population.
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