Experience-dependent contextual codes in the hippocampus.
Experience-dependent contextual codes in the hippocampus.
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DOI：
10.1038/s41593-021-00816-6
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发表时间：
2021-05
影响因子：
25
通讯作者：
Giocomo LM
中科院分区：
文献类型：
--
作者：
Plitt MH;Giocomo LM
The hippocampus contains neural representations capable of supporting declarative memory. Hippocampal place cells are one such representation, firing in one or few locations in a given environment. Between environments, place cell firing fields remap (turning on/off or moving to a new location) to provide a population-wide code for distinct contexts. However, the manner by which contextual features combine to drive hippocampal remapping remains a matter of debate. Using large-scale in vivo two-photon intracellular calcium recordings in mice during virtual navigation, we show that remapping in the hippocampal region CA1 is driven by prior experience regarding the frequency of certain contexts and that remapping approximates an optimal estimate of the identity of the current context. A simple associative-learning mechanism reproduces these results. Together, our findings demonstrate that place cell remapping allows an animal to simultaneously identify its physical location and optimally estimate the identity of the environment.
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DOI：
10.1126/science.1247485
发表时间：
2014-02-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Lovett-Barron M;Kaifosh P;Kheirbek MA;Danielson N;Zaremba JD;Reardon TR;Turi GF;Hen R;Zemelman BV;Losonczy A
通讯作者：
Losonczy A
影响因子：
16.2
作者：
Aronov, Dmitriy;Tank, David W.
通讯作者：
Tank, David W.
影响因子：
19.9
作者：
Fiser, Jozsef;Berkes, Pietro;Orban, Gergo;Lengyel, Mate
通讯作者：
Lengyel, Mate
影响因子：
16.2
作者：
Leutgeb, JK;Leutgeb, S;Moser, EI
通讯作者：
Moser, EI
影响因子：
25
作者：
Dombeck, Daniel A.;Harvey, Christopher D.;Tian, Lin;Looger, Loren L.;Tank, David W.
通讯作者：
Tank, David W.