The relation between thyroid dysregulation and impaired cognition/behaviour: An integrative review.
The relation between thyroid dysregulation and impaired cognition/behaviour: An integrative review.
复制标题
甲状腺调节异常与认知/行为损害的关系：一篇综述。
DOI：
10.1111/jne.12948
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发表时间：
2021-03
影响因子：
3.2
通讯作者：
Sajjadi SA
中科院分区：
文献类型：
--
作者：
Eslami-Amirabadi M;Sajjadi SA
尽管对甲状腺疾病和认知之间的关系进行了数十年的研究，但这种关系的性质仍然难以捉摸。随着年龄的增长，认知障碍和甲状腺功能障碍的患病率一直在上升。此外，甲状腺疾病和认知能力下降之间似乎存在关联。鉴于全球痴呆症负担的增加，阐明甲状腺疾病作为认知损害的潜在可改变危险因素之间的关系是这篇综述的主要目的。我们总结了目前研究甲状腺激素失调与认知或行为之间关系的文献。我们介绍了与甲状腺激素失调相关的脑结构和功能改变的现有影像和病理结果。我们还提出了甲状腺激素、自身抗体和认知/行为之间相互作用的潜在机制。文中还简要讨论了性别、种族和环境因素的影响。这篇综述强调了长期前瞻性研究的必要性，以捕捉与甲状腺功能失调的发生和进展相关的脑功能变化的过程，以及性别和种族等不可改变的风险因素的混杂影响。此外，有必要进行双盲对照临床试验，以制定适当的治疗计划，以防止甲状腺疾病治疗过度或治疗不足造成的认知后果。
Despite decades of research on the relation between thyroid diseases and cognition, the nature of this relationship remains elusive. An increasing prevalence of cognitive impairment and thyroid dysfunction has been consistently observed with ageing. Also, there appears to be an association between thyroid disorders and cognitive decline. Given the increasing global burden of dementia, elucidating the relationship between thyroid disorders as a potentially modifiable risk factor of cognitive impairment was the main goal of this review. We summarise the current literature examining the relationship between thyroid hormonal dysregulation and cognition or behaviour. We present the available imaging and pathological findings related to structural and functional brain changes related to thyroid hormonal dysregulation. We also propose potential mechanisms of interaction between thyroid hormones, autoantibodies and cognition/behaviour. Effects of gender, ethnicity and environmental factors are also briefly discussed. This review highlights the need for long-term prospective studies to capture the course of brain functional changes associated with the incidence and progression of thyroid dysregulations along with the confounding effects of non-modifiable risk factors such as gender and ethnicity. Moreover, double-blind controlled clinical trials are necessary to devise appropriate treatment plans to prevent cognitive consequences of over or undertreatment of thyroid disorders.
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影响因子：
6.3
作者：
Ceresini, Graziano;Lauretani, Fulvio;Maggio, Marcello;Ceda, Gian Paolo;Morganti, Simonetta;Usberti, Elisa;Chezzi, Carlo;Valcavi, Rita;Bandinelli, Stefania;Guralnik, Jack M.;Cappola, Anne R.;Valenti, Giorgio;Ferrucci, Luigi
通讯作者：
Ferrucci, Luigi
影响因子：
3.5
作者：
Bono, G;Fancellu, R;Mauri, M
通讯作者：
Mauri, M
影响因子：
5.8
作者：
Bremner, Alexandra P.;Feddema, Peter;Walsh, John P.
通讯作者：
Walsh, John P.
影响因子：
5.8
作者：
de Jong, Frank Jan;den Heijer, Tom;Breteler, Monique M. B.
通讯作者：
Breteler, Monique M. B.
影响因子：
3.2
作者：
Bell, Robin J.;Rivera-Woll, Livia;Davis, Susan R.
通讯作者：
Davis, Susan R.