In vivo bioluminescent imaging (BLI): noninvasive visualization and interrogation of biological processes in living animals.
In vivo bioluminescent imaging (BLI): noninvasive visualization and interrogation of biological processes in living animals.
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DOI:
10.3390/s110100180
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发表时间:
2011
期刊:
影响因子:
--
通讯作者:
Ripp S
中科院分区:
文献类型:
--
作者:
Close DM;Xu T;Sayler GS;Ripp S
In vivo bioluminescent imaging (BLI) is increasingly being utilized as a method for modern biological research. This process, which involves the noninvasive interrogation of living animals using light emitted from luciferase-expressing bioreporter cells, has been applied to study a wide range of biomolecular functions such as gene function, drug discovery and development, cellular trafficking, protein-protein interactions, and especially tumorigenesis, cancer treatment, and disease progression. This article will review the various bioreporter/biosensor integrations of BLI and discuss how BLI is being applied towards a new visual understanding of biological processes within the living organism.
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