Association of income and education with fecundability in a North American preconception cohort.

Association of income and education with fecundability in a North American preconception cohort.
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DOI:
10.1016/j.annepidem.2020.07.004
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发表时间:
2020-10
影响因子:
5.6
通讯作者:
Wise LA
Wise LA
中科院分区:
医学3区
文献类型:
--
作者:
Schrager NL;Wesselink AK;Wang TR;Hatch EE;Rothman KJ;Mikkelsen EM;Boynton-Jarrett RD;Wise LA

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评估生育力的社会经济决定因素。我们在北美前瞻性队列研究(2013-2019)的 Pregnancy Study Online 中对 8,654 名女性怀孕计划者进行了研究,研究了社会经济地位与生育能力(每个周期受孕概率)之间的关联。通过基线调查问卷收集有关收入和教育的信息。每两个月进行一次随访调查问卷来确定妊娠状况。我们使用比例概率回归估计了生育力比率 (FR) 和 95% 置信区间 (CI),并控制了潜在的混杂因素。相对于家庭年收入≥150,000美元,调整后的FR为:<50,000美元的调整后FR为0.91 (95% CI: 0.83–1.01),50,000-99,000美元的调整后FR为0.99 (95% CI: 0.92–1.07),以及1.09 (95% CI: 1.01–1.18) 100,000 美元至 149,000 美元。相对于≥17年教育,<12年、13-15年和16年教育的FR分别为0.90(95% CI:0.76-1.08)、0.84(95% CI:0.78-0.91)和0.89(95% CI:0.84-0.95)。在老年女性中,收入和教育的关联性稍强一些。较低的教育水平和收入与生育能力的适度降低有关。这些结果表明生育力方面存在社会经济差异。
To evaluate socioeconomic determinants of fecundability. Among 8,654 female pregnancy planners from Pregnancy Study Online, a North American prospective cohort study (2013–2019), we examined associations between socioeconomic status and fecundability (the per-cycle probability of conception). Information on income and education was collected via baseline questionnaire. Bimonthly follow-up questionnaires were used to ascertain pregnancy status. We estimated fecundability ratios (FRs) and 95% confidence intervals (CI) using proportional probabilities regression, controlling for potential confounders. Relative to an annual household income of ≥$150,000, adjusted FRs were 0.91 (95% CI: 0.83–1.01) for <$50,000, 0.99 (95% CI: 0.92–1.07) for $50,000-$99,000, and 1.09 (95% CI: 1.01–1.18) for $100,000-$149,000. FRs for <12, 13–15, and 16 years of education, relative to ≥17 years, were 0.90 (95% CI: 0.76–1.08), 0.84 (95% CI: 0.78–0.91), and 0.89 (95% CI: 0.84–0.95), respectively. Slightly stronger associations for income and education were seen among older women. Lower levels of education and income were associated with modestly reduced fecundability. These results demonstrate the presence of socioeconomic disparities in fecundability.
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