Vestibular Deficits in Neurodegenerative Disorders: Balance, Dizziness, and Spatial Disorientation.
Vestibular Deficits in Neurodegenerative Disorders: Balance, Dizziness, and Spatial Disorientation.
复制标题
DOI：
10.3389/fneur.2017.00538
复制
发表时间：
2017
影响因子：
3.4
通讯作者：
Seemungal BM
中科院分区：
文献类型：
--
作者：
Cronin T;Arshad Q;Seemungal BM
前庭系统由内耳的周围前庭器官和相关的广泛的中枢神经系统投射组成——从小脑和脑干到丘脑中继再到皮质投射。该系统对于空间定向和平衡非常重要，两者都具有至关重要的生态重要性，特别是对于在我们的环境中成功导航而言。平衡障碍和空间定向障碍是神经退行性疾病的常见表现特征；然而，人们对这些疾病的中枢前庭处理知之甚少。中枢前庭处理的一个普遍特征是其混杂性，因为前庭信号通常与其他感觉信号结合在一起。这篇综述讨论了前庭信号中枢处理受损（通常与其他感觉和运动系统相结合）如何解释常见神经退行性疾病中平衡受损和空间定向障碍。这种理解可能提供新的诊断测试，可能有助于检测早期疾病，而对这些患者的不平衡和空间定向障碍的机械理解可能有助于对神经退行性疾病中的此类问题进行前庭靶向治疗。现在非常需要对最先进的中枢前庭测试进行研究来解决这个重要的课题。
The vestibular system consists of the peripheral vestibular organs in the inner ear and the associated extensive central nervous system projections—from the cerebellum and brainstem to the thalamic relays to cortical projections. This system is important for spatial orientation and balance, both of critical ecological importance, particularly for successful navigation in our environment. Balance disorders and spatial disorientation are common presenting features of neurodegenerative diseases; however, little is known regarding central vestibular processing in these diseases. A ubiquitous aspect of central vestibular processing is its promiscuity given that vestibular signals are commonly found in combination with other sensory signals. This review discusses how impaired central processing of vestibular signals—typically in combination with other sensory and motor systems—may account for the impaired balance and spatial disorientation in common neurodegenerative conditions. Such an understanding may provide for new diagnostic tests, potentially useful in detecting early disease while a mechanistic understanding of imbalance and spatial disorientation in these patients may enable a vestibular-targeted therapy for such problems in neurodegenerative diseases. Studies with state of the art central vestibular testing are now much needed to tackle this important topic.
登录
查看更多内容
影响因子：
8.6
作者：
Anderson, Tim;Luxon, Linda;Bronstein, Adolfo
通讯作者：
Bronstein, Adolfo
影响因子：
8.6
作者：
Bisdorff, AR;Bronstein, AM;Lees, AJ
通讯作者：
Lees, AJ
DOI：
10.1111/j.1749-6632.1999.tb09193.x
发表时间：
1999-01-01
期刊：
OTOLITH FUNCTION IN SPATIAL ORIENTATION AND MOVEMENT
影响因子：
--
作者：
Brandt, T;Dieterich, M
通讯作者：
Dieterich, M
影响因子：
4.7
作者：
De Natale, E. R.;Ginatempo, F.;Deriu, F.
通讯作者：
Deriu, F.
影响因子：
6
作者：
Bronstein, Adolfo M.;Golding, John F.;Silove, Yvonne
通讯作者：
Silove, Yvonne