New insights into the aryl hydrocarbon receptor as a modulator of host responses to infection.
New insights into the aryl hydrocarbon receptor as a modulator of host responses to infection.
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DOI：
10.1007/s00281-013-0395-3
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发表时间：
2013-11
影响因子：
9
通讯作者：
Vorderstrasse, Beth A.
中科院分区：
文献类型：
--
作者：
Lawrence, B. Paige;Vorderstrasse, Beth A.
众所周知，宿主对感染的反应受到许多因素的影响，包括遗传、营养状况、年龄以及药物和化学物质的暴露。最近的研究表明，芳香烃受体(AhR)对病毒、细菌和寄生虫的天然免疫和获得性免疫反应有一定的调节作用。虽然许多观察是使用高亲和力但代谢不良的AhR激动剂TCDD进行的，但并不是所有的作用都对宿主有害。有时，激活AhR，即使使用TCDD，也是有益的，并提高了宿主的抵抗力和存活率。在感染AhR缺陷的小鼠中也观察到了类似的二分法，其中功能性AhR的缺失有时但不总是改变宿主的抵抗力。从整体上看，目前的数据表明，AhR控制着多个调节通路，这些调节通路与感染相关的信号汇聚在一起，并且取决于上下文(例如，病原体类型、感染部位)而导致不同的结果。这创造了许多令人兴奋的机会，利用AhR的免疫调节作用来改变宿主对感染的反应。此外，由于许多反应感染性病原体的机制在其他疾病的背景下是关键的，关于AhR的细胞靶点和分子作用机制有许多需要了解的。
The host response to infection is known to be influenced by many factors, including genetics, nutritional status, age, as well as drug and chemical exposures. Recent advances reveal that the aryl hydrocarbon receptor (AhR) modulates aspects of the innate and adaptive immune response to viral, bacterial, and parasitic organisms. Although many of these observations were made using the high affinity but poorly metabolized AhR agonist TCDD, not all of effects are detrimental to the host. Sometimes AhR activation, even with TCDD, was beneficial and improved host resistance and survival. A similar dichotomy is observed in infected AhR-deficient mice, wherein absence of functional AhR sometimes, but not always, alters host resistance. When examined in their totality, current data indicate that AhR controls multiple regulatory pathways that converge with infection-associated signals, and depending on the context (e.g., type of pathogen, site of infection) lead to distinct outcomes. This creates numerous exciting opportunities to harness the immunomodulatory action of AhR to transform host responses to infection. Moreover, since many of the mechanisms cued in response to infectious agents are pivotal in the context of other diseases, there is much to be learned about AhR's cellular targets and molecular mechanisms of action.
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影响因子：
15.8
作者：
Heilmann C;Grandjean P;Weihe P;Nielsen F;Budtz-Jørgensen E
通讯作者：
Budtz-Jørgensen E
影响因子：
11.4
作者：
Chan, Janet K. Y.;Xing, Guan Hua;Wong, Ming H.
通讯作者：
Wong, Ming H.
影响因子：
4.5
作者：
FUNSETH, E;ILBACK, NG
通讯作者：
ILBACK, NG
DOI：
10.1080/15287399009531449
发表时间：
1990-01-01
期刊：
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH
影响因子：
--
作者：
HOUSE, RV;LAUER, LD;DEAN, JH
通讯作者：
DEAN, JH
影响因子：
9.2
作者：
Elizondo G;Rodríguez-Sosa M;Estrada-Muñiz E;Gonzalez FJ;Vega L
通讯作者：
Vega L