The association between polymorphism of INSR and polycystic ovary syndrome: a meta-analysis.
The association between polymorphism of INSR and polycystic ovary syndrome: a meta-analysis.
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INSR 多态性与多囊卵巢综合征之间的关联：荟萃分析。
DOI：
10.3390/ijms16022403
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发表时间：
2015-01-22
影响因子：
5.6
通讯作者：
Jiang SW
中科院分区：
文献类型：
--
作者：
Feng C;Lv PP;Yu TT;Jin M;Shen JM;Wang X;Zhou F;Jiang SW
多囊卵巢综合征（PCOS）是最常见的妇科内分泌疾病。遗传背景被认为在PCOS的发病机制中起着至关重要的作用。近年来，胰岛素受体（INSR）基因多态性在PCOS易感性中的作用引起了广泛关注。我们进行了一项荟萃分析，以调查INSR的单核苷酸多态性（SNPs）和PCOS之间的关联。检索了截至2014年8月7日来自Pubmed、Embase和科克伦CENTRAL的已发表文献。共分析了20项病例对照研究，包括23，845例对照和17，460例PCOS病例，平均Newcastle-Ottawa质量评估量表（NOS）评分为6.75。共检测INSR基因23个外显子及其侧翼区的98个SNPs，其中17个SNPs与PCOS相关。选择在三项以上研究中检测到的三个SNP进行进一步分析。12项研究包括1158名对照和1264名PCOS患者进入rs 1799817分析，但未发现每个基因型之间存在显著关联（p > 0.05）。进一步按种族和体重进行亚组分层，未发现显著相关性（p > 0.05）。对于rs 2059806，包括442例对照和524例PCOS病例的4项研究符合荟萃分析的条件，未发现任何基因型与PCOS有显著关联（p > 0.05）。包括12，830例对照和11，683例PCOS病例在内的四项研究调查了rs 2059807与PCOS之间的相关性，六个队列中有五个显示出显着影响。我们目前的荟萃分析表明rs 1799817/rs 2059806 SNP与PCOS易感性无显著相关性，而rs 2059807可能是一个有希望的候选SNP，可能参与PCOS的易感性。
Polycystic ovary syndrome (PCOS) is the most common gynecological endocrine disorder. The genetic background is believed to play a crucial role in the pathogenesis of PCOS. In recent years, the role of insulin receptor (INSR) polymorphisms in PCOS predisposition has attracted much attention. We performed a meta-analysis to investigate the association between the single nucleotide polymorphisms (SNPs) of INSR and PCOS. Published literature from Pubmed, Embase, and Cochrane CENTRAL was retrieved up until 7 August 2014. A total of 20 case-control studies including 23,845 controls and 17,460 PCOS cases with an average Newcastle-Ottawa quality assessment scale (NOS) score of 6.75 were analyzed. Ninety-eight SNPs distributed in 23 exons and the flanking regions of INSR were investigated, among which 17 SNPs were found to be associated with PCOS. Three SNPs detected in more than three studies were selected for further analyses. Twelve studies including 1158 controls and 1264 PCOS cases entered the analysis of rs1799817, but no significant association was found for every genotype (p > 0.05). Further subgroup stratification by ethnicity and weight did not lead to discovery of significant correlation (p > 0.05). For rs2059806, four studies including 442 controls and 524 PCOS cases were qualified for meta-analysis, and no significant association with PCOS was found for any genotype (p > 0.05). Four studies including 12,830 controls and 11,683 PCOS cases investigated the correlation between rs2059807 and PCOS, and five of the six cohorts indicated a significant impact. Our current meta-analysis suggests no significant correlation between rs1799817/rs2059806 SNPs and susceptibility of PCOS, while rs2059807 could be a promising candidate SNP that might be involved in the susceptibility of PCOS.
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DOI：
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发表时间：
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影响因子：
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