Current trends in West Nile virus vaccine development.
Current trends in West Nile virus vaccine development.
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DOI：
10.1586/14760584.2014.906309
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发表时间：
2014-05
影响因子：
6.2
通讯作者：
Slifka MK
中科院分区：
文献类型：
--
作者：
Amanna IJ;Slifka MK
West Nile virus (WNV) is a mosquito-borne flavivirus that has become endemic in the United States. From 1999-2012, there have been 37,088 reported cases of WNV and 1,549 deaths, resulting in a 4.2% case-fatality rate. Despite development of effective WNV vaccines for horses, there is no vaccine to prevent human WNV infection. Several vaccines have been tested in preclinical studies and to date there have been 8 clinical trials, with promising results in terms of safety and induction of antiviral immunity. Although mass vaccination is unlikely to be cost-effective, implementation of a targeted vaccine program may be feasible if a safe and effective vaccine can be brought to market. Further evaluation of new and advanced vaccine candidates is strongly encouraged.
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影响因子：
7.6
作者：
Amanna, Ian J.;Slifka, Mark K.
通讯作者：
Slifka, Mark K.
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