Cell penetrating elastin-like polypeptides for therapeutic peptide delivery.
Cell penetrating elastin-like polypeptides for therapeutic peptide delivery.
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DOI：
10.1016/j.addr.2010.05.003
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发表时间：
2010-12-30
影响因子：
16.1
通讯作者：
Raucher, Drazen
中科院分区：
文献类型：
--
作者：
Bidwell, Gene L., III;Raucher, Drazen
目前实体瘤的治疗受到药物非特异性递送至肿瘤部位所产生的副作用的限制。针对局部肿瘤的替代靶向治疗方法将显着降低全身毒性。由于肽设计的简便性以及肽对其细胞内分子靶点的特异性，肽治疗是一种有前景的癌症靶向治疗新策略。然而，肽的实用性因其较差的药代动力学参数以及较差的体内组织和细胞膜渗透性而受到限制。本文总结了弹性蛋白样多肽（ELP）作为治疗性肽（TP）热靶向递送的潜在载体的发展，以及使用细胞穿透肽（CPP）来增强ELP融合TP的细胞内递送。 CPP 融合的 ELP 已被用于在多种体外癌症模型中递送 c-Myc 功能的肽抑制剂和 p21 的肽模拟物，并且这两种多肽目前在乳腺癌和脑癌的体内模型中产生了有希望的结果。
Current treatment of solid tumors is limited by side effects that result from the nonspecific delivery of drugs to the tumor site. Alternative targeted therapeutic approaches for localized tumors would significantly reduce systemic toxicity. Peptide therapeutics are a promising new strategy for targeted cancer therapy because of the ease of peptide design and the specificity of peptides for their intracellular molecular targets. However, the utility of peptides is limited by their poor pharmacokinetic parameters and poor tissue and cellular membrane permeability in vivo. This review article summarizes the development of elastin-like polypeptide (ELP) as a potential carrier for thermally targeted delivery of therapeutic peptides (TP), and the use of cell penetrating peptides (CPP) to enhance the intracellular delivery of the ELP-fused TPs. CPP-fused ELPs have been used to deliver a peptide inhibitor of c-Myc function and a peptide mimetic of p21 in several cancer models in vitro, and both polypeptides are currently yielding promising results in in vivo models of breast and brain cancer.
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影响因子：
7.3
作者：
Heitz F;Morris MC;Divita G
通讯作者：
Divita G
影响因子：
19
作者：
Derossi, D;Chassaing, G;Prochiantz, A
通讯作者：
Prochiantz, A
影响因子：
5.8
作者：
Bidwell, GL;Raucher, D
通讯作者：
Raucher, D
影响因子：
3.7
作者：
Chen, Tze-Haw Howard;Bae, Younsoo;Furgeson, Darin Y.
通讯作者：
Furgeson, Darin Y.
影响因子：
5.8
作者：
Bidwell, Gene L., III;Fokt, Izabela;Raucher, Drazen
通讯作者：
Raucher, Drazen